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Rho/ROCK Signal Cascade Mediates Asymmetric Dimethylarginine-Induced Vascular Smooth Muscle Cells Migration and Phenotype Change

Asymmetric dimethylarginine (ADMA) induces vascular smooth muscle cells (VSMCs) migration. VSMC phenotype change is a prerequisite of migration. RhoA and Rho-kinase (ROCK) mediate migration of VSMCs. We hypothesize that ADMA induces VSMC migration via the activation of Rho/ROCK signal pathway and du...

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Detalles Bibliográficos
Autores principales:	Zhou, Yi-ming, Lan, Xi, Guo, Han-bin, Zhang, Yan, Ma, Li, Cao, Jian-biao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119924/ https://www.ncbi.nlm.nih.gov/pubmed/25121106 http://dx.doi.org/10.1155/2014/683707

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