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Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties

ES-62, a glycoprotein secreted by the filarial nematode Acanthocheilonema viteae, exhibits anti-inflammatory properties by virtue of covalently attached phosphorylcholine moieties. Screening of a library of ES-62 phosphorylcholine-based small molecule analogues (SMAs) revealed that two compounds, te...

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Autores principales: Rzepecka, Justyna, Coates, Michelle L., Saggar, Moninder, Al-Riyami, Lamyaa, Coltherd, Jennifer, Tay, Hwee Kee, Huggan, Judith K., Janicova, Lucia, Khalaf, Abedawn I., Siebeke, Ivonne, Suckling, Colin J., Harnett, Margaret M., Harnett, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119935/
https://www.ncbi.nlm.nih.gov/pubmed/24929132
http://dx.doi.org/10.1016/j.ijpara.2014.05.001
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author Rzepecka, Justyna
Coates, Michelle L.
Saggar, Moninder
Al-Riyami, Lamyaa
Coltherd, Jennifer
Tay, Hwee Kee
Huggan, Judith K.
Janicova, Lucia
Khalaf, Abedawn I.
Siebeke, Ivonne
Suckling, Colin J.
Harnett, Margaret M.
Harnett, William
author_facet Rzepecka, Justyna
Coates, Michelle L.
Saggar, Moninder
Al-Riyami, Lamyaa
Coltherd, Jennifer
Tay, Hwee Kee
Huggan, Judith K.
Janicova, Lucia
Khalaf, Abedawn I.
Siebeke, Ivonne
Suckling, Colin J.
Harnett, Margaret M.
Harnett, William
author_sort Rzepecka, Justyna
collection PubMed
description ES-62, a glycoprotein secreted by the filarial nematode Acanthocheilonema viteae, exhibits anti-inflammatory properties by virtue of covalently attached phosphorylcholine moieties. Screening of a library of ES-62 phosphorylcholine-based small molecule analogues (SMAs) revealed that two compounds, termed 11a and 12b, mirrored the helminth product both in inhibiting mast cell degranulation and cytokine responses in vitro and in preventing ovalbumin-induced Th2-associated airway inflammation and eosinophil infiltration of the lungs in mice. Furthermore, the two SMAs inhibited neutrophil infiltration of the lungs when administered therapeutically. ES-62-SMAs 11a and 12b thus represent starting points for novel drug development for allergies such as asthma.
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spelling pubmed-41199352014-08-07 Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties Rzepecka, Justyna Coates, Michelle L. Saggar, Moninder Al-Riyami, Lamyaa Coltherd, Jennifer Tay, Hwee Kee Huggan, Judith K. Janicova, Lucia Khalaf, Abedawn I. Siebeke, Ivonne Suckling, Colin J. Harnett, Margaret M. Harnett, William Int J Parasitol Succinctus ES-62, a glycoprotein secreted by the filarial nematode Acanthocheilonema viteae, exhibits anti-inflammatory properties by virtue of covalently attached phosphorylcholine moieties. Screening of a library of ES-62 phosphorylcholine-based small molecule analogues (SMAs) revealed that two compounds, termed 11a and 12b, mirrored the helminth product both in inhibiting mast cell degranulation and cytokine responses in vitro and in preventing ovalbumin-induced Th2-associated airway inflammation and eosinophil infiltration of the lungs in mice. Furthermore, the two SMAs inhibited neutrophil infiltration of the lungs when administered therapeutically. ES-62-SMAs 11a and 12b thus represent starting points for novel drug development for allergies such as asthma. Elsevier Science 2014-08 /pmc/articles/PMC4119935/ /pubmed/24929132 http://dx.doi.org/10.1016/j.ijpara.2014.05.001 Text en © 2014 The Authors http://creativecommons.org/licenses/by/3.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Succinctus
Rzepecka, Justyna
Coates, Michelle L.
Saggar, Moninder
Al-Riyami, Lamyaa
Coltherd, Jennifer
Tay, Hwee Kee
Huggan, Judith K.
Janicova, Lucia
Khalaf, Abedawn I.
Siebeke, Ivonne
Suckling, Colin J.
Harnett, Margaret M.
Harnett, William
Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties
title Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties
title_full Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties
title_fullStr Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties
title_full_unstemmed Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties
title_short Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties
title_sort small molecule analogues of the immunomodulatory parasitic helminth product es-62 have anti-allergy properties
topic Succinctus
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119935/
https://www.ncbi.nlm.nih.gov/pubmed/24929132
http://dx.doi.org/10.1016/j.ijpara.2014.05.001
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