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Post-weaning diet determines metabolic risk in mice exposed to overnutrition in early life

BACKGROUND: Maternal overnutrition during pregnancy is associated with an increased risk of obesity and cardiometabolic disease in the offspring; a phenomenon attributed to ‘developmental programming’. The post-weaning development of obesity may associate with exacerbation of the programmed metaboli...

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Autores principales: King, Vicky, Norman, Jane E, Seckl, Jonathan R, Drake, Amanda J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120004/
https://www.ncbi.nlm.nih.gov/pubmed/25082159
http://dx.doi.org/10.1186/1477-7827-12-73
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author King, Vicky
Norman, Jane E
Seckl, Jonathan R
Drake, Amanda J
author_facet King, Vicky
Norman, Jane E
Seckl, Jonathan R
Drake, Amanda J
author_sort King, Vicky
collection PubMed
description BACKGROUND: Maternal overnutrition during pregnancy is associated with an increased risk of obesity and cardiometabolic disease in the offspring; a phenomenon attributed to ‘developmental programming’. The post-weaning development of obesity may associate with exacerbation of the programmed metabolic phenotype. In mice, we have previously shown that exposure to maternal overnutrition causes increased weight gain in offspring before weaning, but exerts no persistent effects on weight or glucose tolerance in adulthood. In order to determine whether post-weaning exposure to a cafeteria diet might lead to an exacerbation of programmed effects, offspring born and raised by mothers on control (CON) or cafeteria (DIO) diets were transferred onto either CON or DIO diets at weaning. FINDINGS: Post-weaning DIO caused the development of obesity, with hyperglycaemia and hyperinsulinaemia in males; and obesity with hyperinsulinaemia in females and with increased cholesterol levels in both sexes. Exposure to maternal overnutrition during pregnancy and lactation caused only subtle additional effects on offspring phenotype. CONCLUSIONS: These results suggest that post-weaning exposure to a high-fat high-sugar diet has a more profound effect on offspring weight gain and glucose tolerance than exposure to maternal overnutrition. These data emphasise the importance of optimising early life nutrition in offspring of both obese and lean mothers.
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spelling pubmed-41200042014-08-05 Post-weaning diet determines metabolic risk in mice exposed to overnutrition in early life King, Vicky Norman, Jane E Seckl, Jonathan R Drake, Amanda J Reprod Biol Endocrinol Short Communication BACKGROUND: Maternal overnutrition during pregnancy is associated with an increased risk of obesity and cardiometabolic disease in the offspring; a phenomenon attributed to ‘developmental programming’. The post-weaning development of obesity may associate with exacerbation of the programmed metabolic phenotype. In mice, we have previously shown that exposure to maternal overnutrition causes increased weight gain in offspring before weaning, but exerts no persistent effects on weight or glucose tolerance in adulthood. In order to determine whether post-weaning exposure to a cafeteria diet might lead to an exacerbation of programmed effects, offspring born and raised by mothers on control (CON) or cafeteria (DIO) diets were transferred onto either CON or DIO diets at weaning. FINDINGS: Post-weaning DIO caused the development of obesity, with hyperglycaemia and hyperinsulinaemia in males; and obesity with hyperinsulinaemia in females and with increased cholesterol levels in both sexes. Exposure to maternal overnutrition during pregnancy and lactation caused only subtle additional effects on offspring phenotype. CONCLUSIONS: These results suggest that post-weaning exposure to a high-fat high-sugar diet has a more profound effect on offspring weight gain and glucose tolerance than exposure to maternal overnutrition. These data emphasise the importance of optimising early life nutrition in offspring of both obese and lean mothers. BioMed Central 2014-08-01 /pmc/articles/PMC4120004/ /pubmed/25082159 http://dx.doi.org/10.1186/1477-7827-12-73 Text en Copyright © 2014 King et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Short Communication
King, Vicky
Norman, Jane E
Seckl, Jonathan R
Drake, Amanda J
Post-weaning diet determines metabolic risk in mice exposed to overnutrition in early life
title Post-weaning diet determines metabolic risk in mice exposed to overnutrition in early life
title_full Post-weaning diet determines metabolic risk in mice exposed to overnutrition in early life
title_fullStr Post-weaning diet determines metabolic risk in mice exposed to overnutrition in early life
title_full_unstemmed Post-weaning diet determines metabolic risk in mice exposed to overnutrition in early life
title_short Post-weaning diet determines metabolic risk in mice exposed to overnutrition in early life
title_sort post-weaning diet determines metabolic risk in mice exposed to overnutrition in early life
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120004/
https://www.ncbi.nlm.nih.gov/pubmed/25082159
http://dx.doi.org/10.1186/1477-7827-12-73
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