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Mechanistic Modeling Reveals the Critical Knowledge Gaps in Bile Acid–Mediated DILI

Bile salt export pump (BSEP) inhibition has been proposed to be an important mechanism for drug-induced liver injury (DILI). Modeling can prioritize knowledge gaps concerning bile acid (BA) homeostasis and thus help guide experimentation. A submodel of BA homeostasis in rats and humans was construct...

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Detalles Bibliográficos
Autores principales:	Woodhead, J L, Yang, K, Brouwer, K L R, Siler, S Q, Stahl, S H, Ambroso, J L, Baker, D, Watkins, P B, Howell, B A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120015/ https://www.ncbi.nlm.nih.gov/pubmed/25006780 http://dx.doi.org/10.1038/psp.2014.21

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