Clinical Translation in the Virtual Liver Network

The liver is the central detoxifying organ, continuously removing xenobiotics from the vascular system. Given its role in drug metabolism, a functional understanding of liver physiology is crucial to optimizing drug efficacy and patient safety. The Virtual Liver Network (VLN), a German national flag...

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Detalles Bibliográficos
Autores principales: Kuepfer, L, Kerb, R, Henney, A M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120019/
https://www.ncbi.nlm.nih.gov/pubmed/25076067
http://dx.doi.org/10.1038/psp.2014.25
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author Kuepfer, L
Kerb, R
Henney, A M
author_facet Kuepfer, L
Kerb, R
Henney, A M
author_sort Kuepfer, L
collection PubMed
description The liver is the central detoxifying organ, continuously removing xenobiotics from the vascular system. Given its role in drug metabolism, a functional understanding of liver physiology is crucial to optimizing drug efficacy and patient safety. The Virtual Liver Network (VLN), a German national flagship research program, focuses on producing validated computer models of human liver physiology. These models are used to analyze patient-derived data and thereby gain mechanistic insights in the processes underlying drug pharmacokinetics (PK).
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spelling pubmed-41200192014-08-15 Clinical Translation in the Virtual Liver Network Kuepfer, L Kerb, R Henney, A M CPT Pharmacometrics Syst Pharmacol Perspective The liver is the central detoxifying organ, continuously removing xenobiotics from the vascular system. Given its role in drug metabolism, a functional understanding of liver physiology is crucial to optimizing drug efficacy and patient safety. The Virtual Liver Network (VLN), a German national flagship research program, focuses on producing validated computer models of human liver physiology. These models are used to analyze patient-derived data and thereby gain mechanistic insights in the processes underlying drug pharmacokinetics (PK). Nature Publishing Group 2014-07 2014-07-30 /pmc/articles/PMC4120019/ /pubmed/25076067 http://dx.doi.org/10.1038/psp.2014.25 Text en Copyright © 2014 American Society for Clinical Pharmacology and Therapeutics http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Perspective
Kuepfer, L
Kerb, R
Henney, A M
Clinical Translation in the Virtual Liver Network
title Clinical Translation in the Virtual Liver Network
title_full Clinical Translation in the Virtual Liver Network
title_fullStr Clinical Translation in the Virtual Liver Network
title_full_unstemmed Clinical Translation in the Virtual Liver Network
title_short Clinical Translation in the Virtual Liver Network
title_sort clinical translation in the virtual liver network
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120019/
https://www.ncbi.nlm.nih.gov/pubmed/25076067
http://dx.doi.org/10.1038/psp.2014.25
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