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Chemical Tuning Enhances Both Potency Toward Nrf2 and In Vitro Therapeutic Index of Triterpenoids

The transcription factor Nrf2 protects against a number of experimental pathologies, and is a promising therapeutic target. The clinical investigation of a potent Nrf2-inducing agent, the triterpenoid (TP) bardoxolone methyl (BARD), was recently halted due to adverse cardiovascular events in chronic...

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Detalles Bibliográficos
Autores principales:	Copple, Ian M., Shelton, Luke M., Walsh, Joanne, Kratschmar, Denise V., Lister, Adam, Odermatt, Alex, Goldring, Christopher E., Dinkova-Kostova, Albena T., Honda, Tadashi, Park, B. Kevin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Safety Evaluation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120102/ https://www.ncbi.nlm.nih.gov/pubmed/24798383 http://dx.doi.org/10.1093/toxsci/kfu080

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