The Histone Methyltransferase Activity of MLL1 Is Dispensable for Hematopoiesis and Leukemogenesis

Despite correlations between histone methyltransferase (HMT) activity and gene regulation, direct evidence that HMT activity is responsible for gene activation is sparse. We address the role of the HMT activity for MLL1, a histone H3 lysine 4 (H3K4) methyltransferase critical for maintaining hematop...

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Detalles Bibliográficos
Autores principales: Mishra, Bibhu P., Zaffuto, Kristin M., Artinger, Erika L., Org, Tonis, Mikkola, Hanna K.A., Cheng, Chao, Djabali, Malek, Ernst, Patricia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120120/
https://www.ncbi.nlm.nih.gov/pubmed/24813891
http://dx.doi.org/10.1016/j.celrep.2014.04.015

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