Cardiac preconditioning with sphingosine-1-phosphate requires activation of signal transducer and activator of transcription-3

AIMS: Sphingosine-1-phosphate (S1P) is a cardioprotective agent. Signal transducer and activator of transcription 3 (STAT-3) is a key mediator of many cardioprotective agents. We aimed to explore whether STAT-3 is a key mediator in S1P-induced preconditioning. METHODS: Langendorff-perfused hearts fr...

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Detalles Bibliográficos
Autores principales: Kelly-Laubscher, Roisin F, King, Jonathan C, Hacking, Damian, Somers, Sarin, Hastie, Samantha, Stewart, Tessa, Imamdin, Aqeela, Maarman, Gerald, Pedretti, Sarah, Lecour, Sandrine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Clinics Cardive Publishing 2014
Materias:
Cardiovascular Topics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120131/
https://www.ncbi.nlm.nih.gov/pubmed/25000441
http://dx.doi.org/10.5830/CVJA-2014-016

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