Shared VH1-46 gene usage by pemphigus vulgaris autoantibodies indicates common humoral immune responses among patients

Pemphigus vulgaris (PV) is a potentially fatal blistering disease caused by autoantibodies against desmoglein 3 (Dsg3). Here, we clone anti-Dsg3 antibodies from four PV patients and identify pathogenic VH1-46 autoantibodies from all four patients. Unexpectedly, VH1-46 autoantibodies had relatively f...

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Detalles Bibliográficos
Autores principales: Cho, Michael Jeffrey, Lo, Agnes S.Y., Mao, Xuming, Nagler, Arielle R., Ellebrecht, Christoph T., Mukherjee, Eric M., Hammers, Christoph M., Choi, Eun-Jung, Sharma, Preety M., Uduman, Mohamed, Li, Hong, Rux, Ann H., Farber, Sara A., Rubin, Courtney B., Kleinstein, Steven H., Sachais, Bruce S., Posner, Marshall R., Cavacini, Lisa A., Payne, Aimee S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120239/
https://www.ncbi.nlm.nih.gov/pubmed/24942562
http://dx.doi.org/10.1038/ncomms5167

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