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Minimally invasive endoscopic staging for mediastinal lymphadenopathy in lung cancer: a systematic review protocol

INTRODUCTION: Minimally invasive endoscopic biopsy techniques have been widely available as potential alternatives for mediastinal lesions staging in patients with known or suspected lung cancer. Previous efforts have been made to evaluate the diagnostic performance of specific endoscopic modality a...

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Autores principales: Liu, Hong, Zhou, Jie, Feng, Qiao-ling, Wan, Gang, Xie, Yong-jun, Gu, Hai-tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120311/
https://www.ncbi.nlm.nih.gov/pubmed/25082423
http://dx.doi.org/10.1136/bmjopen-2014-005707
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author Liu, Hong
Zhou, Jie
Feng, Qiao-ling
Wan, Gang
Xie, Yong-jun
Gu, Hai-tao
author_facet Liu, Hong
Zhou, Jie
Feng, Qiao-ling
Wan, Gang
Xie, Yong-jun
Gu, Hai-tao
author_sort Liu, Hong
collection PubMed
description INTRODUCTION: Minimally invasive endoscopic biopsy techniques have been widely available as potential alternatives for mediastinal lesions staging in patients with known or suspected lung cancer. Previous efforts have been made to evaluate the diagnostic performance of specific endoscopic modality alone at the level of the mediastinum for staging lung cancer, however, few studies focus on the accuracy of comparisons between different endoscopic modalities, especially at the level of any individual lymph node station. The objective of our study is to determine the diagnostic yields of different endoscopic modalities for staging mediastinal lymphadenopathy in lung cancer, especially concerning the individual lymph node station. METHODS/DESIGN: A systematic electronic search of MEDLINE, EMBASE, SinoMed and ISI Web of Science were performed to identify studies evaluating endoscopic modalities accuracy with restriction of English and Chinese languages from inception to an update until May 2014. Data were extracted with the patient as the unit of analysis with regards to the abilities of different endoscopic modalities at the level of mediastinum and particular lymph node station. The methodological quality was assessed independently according to the Quality Assessment of Diagnostic Accuracy Study (QADAS) criteria. An exact binomial rendition of bivariate mixed-effects regression model was used to estimate the pooled sensitivity and specificity. Also, pre–post probability analysis, publication bias analysis and sensitivity analysis were performed for a synthesis of knowledge of this context. DISSEMINATION: The findings will advance our better available knowledge of optimal clinical decision-making when dealing with staging of mediastinal metastasis in lung cancer. TRIAL REGISTRATION NUMBER: PROSPERO—NIHR Prospective Register of Systematic Reviews (CRD42014009792).
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spelling pubmed-41203112014-08-05 Minimally invasive endoscopic staging for mediastinal lymphadenopathy in lung cancer: a systematic review protocol Liu, Hong Zhou, Jie Feng, Qiao-ling Wan, Gang Xie, Yong-jun Gu, Hai-tao BMJ Open Surgery INTRODUCTION: Minimally invasive endoscopic biopsy techniques have been widely available as potential alternatives for mediastinal lesions staging in patients with known or suspected lung cancer. Previous efforts have been made to evaluate the diagnostic performance of specific endoscopic modality alone at the level of the mediastinum for staging lung cancer, however, few studies focus on the accuracy of comparisons between different endoscopic modalities, especially at the level of any individual lymph node station. The objective of our study is to determine the diagnostic yields of different endoscopic modalities for staging mediastinal lymphadenopathy in lung cancer, especially concerning the individual lymph node station. METHODS/DESIGN: A systematic electronic search of MEDLINE, EMBASE, SinoMed and ISI Web of Science were performed to identify studies evaluating endoscopic modalities accuracy with restriction of English and Chinese languages from inception to an update until May 2014. Data were extracted with the patient as the unit of analysis with regards to the abilities of different endoscopic modalities at the level of mediastinum and particular lymph node station. The methodological quality was assessed independently according to the Quality Assessment of Diagnostic Accuracy Study (QADAS) criteria. An exact binomial rendition of bivariate mixed-effects regression model was used to estimate the pooled sensitivity and specificity. Also, pre–post probability analysis, publication bias analysis and sensitivity analysis were performed for a synthesis of knowledge of this context. DISSEMINATION: The findings will advance our better available knowledge of optimal clinical decision-making when dealing with staging of mediastinal metastasis in lung cancer. TRIAL REGISTRATION NUMBER: PROSPERO—NIHR Prospective Register of Systematic Reviews (CRD42014009792). BMJ Publishing Group 2014-07-31 /pmc/articles/PMC4120311/ /pubmed/25082423 http://dx.doi.org/10.1136/bmjopen-2014-005707 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Surgery
Liu, Hong
Zhou, Jie
Feng, Qiao-ling
Wan, Gang
Xie, Yong-jun
Gu, Hai-tao
Minimally invasive endoscopic staging for mediastinal lymphadenopathy in lung cancer: a systematic review protocol
title Minimally invasive endoscopic staging for mediastinal lymphadenopathy in lung cancer: a systematic review protocol
title_full Minimally invasive endoscopic staging for mediastinal lymphadenopathy in lung cancer: a systematic review protocol
title_fullStr Minimally invasive endoscopic staging for mediastinal lymphadenopathy in lung cancer: a systematic review protocol
title_full_unstemmed Minimally invasive endoscopic staging for mediastinal lymphadenopathy in lung cancer: a systematic review protocol
title_short Minimally invasive endoscopic staging for mediastinal lymphadenopathy in lung cancer: a systematic review protocol
title_sort minimally invasive endoscopic staging for mediastinal lymphadenopathy in lung cancer: a systematic review protocol
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120311/
https://www.ncbi.nlm.nih.gov/pubmed/25082423
http://dx.doi.org/10.1136/bmjopen-2014-005707
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