Cargando…
Prevention of surgical site infection in lower limb skin lesion excisions with single dose oral antibiotic prophylaxis: a prospective randomised placebo-controlled double-blind trial
OBJECTIVES: To determine the effectiveness of a single perioperative prophylactic 2 g dose of cephalexin in preventing surgical site infection (SSI) following excision of skin lesions from the lower limb. DESIGN: Prospective double-blinded placebo-controlled trial testing for difference in infection...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120377/ https://www.ncbi.nlm.nih.gov/pubmed/25079934 http://dx.doi.org/10.1136/bmjopen-2014-005270 |
_version_ | 1782329079075176448 |
---|---|
author | Smith, Samuel C Heal, Clare F Buttner, Petra G |
author_facet | Smith, Samuel C Heal, Clare F Buttner, Petra G |
author_sort | Smith, Samuel C |
collection | PubMed |
description | OBJECTIVES: To determine the effectiveness of a single perioperative prophylactic 2 g dose of cephalexin in preventing surgical site infection (SSI) following excision of skin lesions from the lower limb. DESIGN: Prospective double-blinded placebo-controlled trial testing for difference in infection rates. SETTING: Primary care in regional North Queensland, Australia. PARTICIPANTS: 52 patients undergoing lower limb skin lesion excision. INTERVENTIONS: 2 g dose of cephalexin 30–60 min before excision. MAIN OUTCOME MEASURES: Incidence of SSI. RESULTS: Incidence of SSI was 12.5% (95% CI 2.7% to 32.4%) in the cephalexin group compared with 35.7% (95% CI 18.6% to 55.9%) in the placebo group (p=0.064). This represented an absolute reduction of 23.21% (95% CI −0.39% to 46.82%), relative reduction of 65.00% (95% CI −12.70% to 89.13%) and number-needed-to-treat of 4.3. CONCLUSIONS: Administration of a single 2 g dose of cephalexin 30–60 min before skin lesion excision from the lower limb may produce a reduction in the incidence of infection; however, this study was underpowered to statistically determine this. TRIAL REGISTRATION NUMBER: ACTRN12611000595910. |
format | Online Article Text |
id | pubmed-4120377 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-41203772014-08-05 Prevention of surgical site infection in lower limb skin lesion excisions with single dose oral antibiotic prophylaxis: a prospective randomised placebo-controlled double-blind trial Smith, Samuel C Heal, Clare F Buttner, Petra G BMJ Open Dermatology OBJECTIVES: To determine the effectiveness of a single perioperative prophylactic 2 g dose of cephalexin in preventing surgical site infection (SSI) following excision of skin lesions from the lower limb. DESIGN: Prospective double-blinded placebo-controlled trial testing for difference in infection rates. SETTING: Primary care in regional North Queensland, Australia. PARTICIPANTS: 52 patients undergoing lower limb skin lesion excision. INTERVENTIONS: 2 g dose of cephalexin 30–60 min before excision. MAIN OUTCOME MEASURES: Incidence of SSI. RESULTS: Incidence of SSI was 12.5% (95% CI 2.7% to 32.4%) in the cephalexin group compared with 35.7% (95% CI 18.6% to 55.9%) in the placebo group (p=0.064). This represented an absolute reduction of 23.21% (95% CI −0.39% to 46.82%), relative reduction of 65.00% (95% CI −12.70% to 89.13%) and number-needed-to-treat of 4.3. CONCLUSIONS: Administration of a single 2 g dose of cephalexin 30–60 min before skin lesion excision from the lower limb may produce a reduction in the incidence of infection; however, this study was underpowered to statistically determine this. TRIAL REGISTRATION NUMBER: ACTRN12611000595910. BMJ Publishing Group 2014-07-30 /pmc/articles/PMC4120377/ /pubmed/25079934 http://dx.doi.org/10.1136/bmjopen-2014-005270 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Dermatology Smith, Samuel C Heal, Clare F Buttner, Petra G Prevention of surgical site infection in lower limb skin lesion excisions with single dose oral antibiotic prophylaxis: a prospective randomised placebo-controlled double-blind trial |
title | Prevention of surgical site infection in lower limb skin lesion excisions with single dose oral antibiotic prophylaxis: a prospective randomised placebo-controlled double-blind trial |
title_full | Prevention of surgical site infection in lower limb skin lesion excisions with single dose oral antibiotic prophylaxis: a prospective randomised placebo-controlled double-blind trial |
title_fullStr | Prevention of surgical site infection in lower limb skin lesion excisions with single dose oral antibiotic prophylaxis: a prospective randomised placebo-controlled double-blind trial |
title_full_unstemmed | Prevention of surgical site infection in lower limb skin lesion excisions with single dose oral antibiotic prophylaxis: a prospective randomised placebo-controlled double-blind trial |
title_short | Prevention of surgical site infection in lower limb skin lesion excisions with single dose oral antibiotic prophylaxis: a prospective randomised placebo-controlled double-blind trial |
title_sort | prevention of surgical site infection in lower limb skin lesion excisions with single dose oral antibiotic prophylaxis: a prospective randomised placebo-controlled double-blind trial |
topic | Dermatology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120377/ https://www.ncbi.nlm.nih.gov/pubmed/25079934 http://dx.doi.org/10.1136/bmjopen-2014-005270 |
work_keys_str_mv | AT smithsamuelc preventionofsurgicalsiteinfectioninlowerlimbskinlesionexcisionswithsingledoseoralantibioticprophylaxisaprospectiverandomisedplacebocontrolleddoubleblindtrial AT healclaref preventionofsurgicalsiteinfectioninlowerlimbskinlesionexcisionswithsingledoseoralantibioticprophylaxisaprospectiverandomisedplacebocontrolleddoubleblindtrial AT buttnerpetrag preventionofsurgicalsiteinfectioninlowerlimbskinlesionexcisionswithsingledoseoralantibioticprophylaxisaprospectiverandomisedplacebocontrolleddoubleblindtrial |