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Resting state functional connectivity in the human spinal cord
Functional magnetic resonance imaging using blood oxygenation level dependent (BOLD) contrast is well established as one of the most powerful methods for mapping human brain function. Numerous studies have measured how low-frequency BOLD signal fluctuations from the brain are correlated between voxe...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120419/ https://www.ncbi.nlm.nih.gov/pubmed/25097248 http://dx.doi.org/10.7554/eLife.02812 |
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author | Barry, Robert L Smith, Seth A Dula, Adrienne N Gore, John C |
author_facet | Barry, Robert L Smith, Seth A Dula, Adrienne N Gore, John C |
author_sort | Barry, Robert L |
collection | PubMed |
description | Functional magnetic resonance imaging using blood oxygenation level dependent (BOLD) contrast is well established as one of the most powerful methods for mapping human brain function. Numerous studies have measured how low-frequency BOLD signal fluctuations from the brain are correlated between voxels in a resting state, and have exploited these signals to infer functional connectivity within specific neural circuits. However, to date there have been no previous substantiated reports of resting state correlations in the spinal cord. In a cohort of healthy volunteers, we observed robust functional connectivity between left and right ventral (motor) horns, and between left and right dorsal (sensory) horns. Our results demonstrate that low-frequency BOLD fluctuations are inherent in the spinal cord as well as the brain, and by analogy to cortical circuits, we hypothesize that these correlations may offer insight into the execution and maintenance of sensory and motor functions both locally and within the cerebrum. DOI: http://dx.doi.org/10.7554/eLife.02812.001 |
format | Online Article Text |
id | pubmed-4120419 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-41204192014-08-22 Resting state functional connectivity in the human spinal cord Barry, Robert L Smith, Seth A Dula, Adrienne N Gore, John C eLife Neuroscience Functional magnetic resonance imaging using blood oxygenation level dependent (BOLD) contrast is well established as one of the most powerful methods for mapping human brain function. Numerous studies have measured how low-frequency BOLD signal fluctuations from the brain are correlated between voxels in a resting state, and have exploited these signals to infer functional connectivity within specific neural circuits. However, to date there have been no previous substantiated reports of resting state correlations in the spinal cord. In a cohort of healthy volunteers, we observed robust functional connectivity between left and right ventral (motor) horns, and between left and right dorsal (sensory) horns. Our results demonstrate that low-frequency BOLD fluctuations are inherent in the spinal cord as well as the brain, and by analogy to cortical circuits, we hypothesize that these correlations may offer insight into the execution and maintenance of sensory and motor functions both locally and within the cerebrum. DOI: http://dx.doi.org/10.7554/eLife.02812.001 eLife Sciences Publications, Ltd 2014-08-05 /pmc/articles/PMC4120419/ /pubmed/25097248 http://dx.doi.org/10.7554/eLife.02812 Text en Copyright © 2014, Barry et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Barry, Robert L Smith, Seth A Dula, Adrienne N Gore, John C Resting state functional connectivity in the human spinal cord |
title | Resting state functional connectivity in the human spinal cord |
title_full | Resting state functional connectivity in the human spinal cord |
title_fullStr | Resting state functional connectivity in the human spinal cord |
title_full_unstemmed | Resting state functional connectivity in the human spinal cord |
title_short | Resting state functional connectivity in the human spinal cord |
title_sort | resting state functional connectivity in the human spinal cord |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120419/ https://www.ncbi.nlm.nih.gov/pubmed/25097248 http://dx.doi.org/10.7554/eLife.02812 |
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