Cargando…

Pharmacophore Modeling and Molecular Docking Studies on Pinus roxburghii as a Target for Diabetes Mellitus

The present study attempts to establish a relationship between ethnopharmacological claims and bioactive constituents present in Pinus roxburghii against all possible targets for diabetes through molecular docking and to develop a pharmacophore model for the active target. The process of molecular d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kaushik, Pawan, Lal Khokra, Sukhbir, Rana, A. C., Kaushik, Dhirender
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120483/ https://www.ncbi.nlm.nih.gov/pubmed/25114678 http://dx.doi.org/10.1155/2014/903246

Ejemplares similares

Analgesic and Anti-Inflammatory Activity of Pinus roxburghii Sarg.
por: Kaushik, Dhirender, et al.
Publicado: (2012)

Quinoline based furanones and their nitrogen analogues: Docking, synthesis and biological evaluation
por: Khokra, Sukhbir Lal, et al.
Publicado: (2016)

Volatile constituents of Pinus roxburghii from Nepal
por: Satyal, Prabodh, et al.
Publicado: (2013)

Studies of Phytochemicals, Antioxidant, and Antibacterial Activities of Pinus gerardiana and Pinus roxburghii Seed Extracts
por: Bhardwaj, Kanchan, et al.
Publicado: (2022)

Synthesis, Computational Studies and Anticonvulsant Activity of Novel Benzothiazole Coupled Sulfonamide Derivatives
por: Khokra, Sukhbir L., et al.
Publicado: (2019)

Pinus Roxburghii essential oil anticancer activity and chemical composition evaluation
por: Sajid, Arfaa, et al.
Publicado: (2018)

Triazole analogues as potential pharmacological agents: a brief review
por: Kumar, Sachin, et al.
Publicado: (2021)

Reproductive Ecology of Male and Female Strobili and Mating System in Two Different Populations of Pinus roxburghii
por: Sharma, Chandra Mohan, et al.
Publicado: (2012)

FTIR and GC–MS spectral datasets of wax from Pinus roxburghii Sarg. needles biomass
por: Dubey, Pallavi, et al.
Publicado: (2017)

In silico Discovery of Novel FXa Inhibitors by Pharmacophore Modeling and Molecular Docking
por: Pu, Yinglan, et al.
Publicado: (2017)

Discovery of Novel Coumarin Analogs against the α-Glucosidase Protein Target of Diabetes Mellitus: Pharmacophore-Based QSAR, Docking, and Molecular Dynamics Simulation Studies
por: Maurya, Akhilesh Kumar, et al.
Publicado: (2020)

Identification of New Potential APE1 Inhibitors by Pharmacophore Modeling and Molecular Docking
por: Lee, In Won, et al.
Publicado: (2017)

Pharmacophore elucidation and molecular docking studies on phosphodiesterase-5 inhibitors
por: Radwan, Awwad Abdoh
Publicado: (2015)

PharmDock: a pharmacophore-based docking program
por: Hu, Bingjie, et al.
Publicado: (2014)

Pharmacophore-Based Similarity Scoring for DOCK
por: Jiang, Lingling, et al.
Publicado: (2014)

Search for the Pharmacophore of Histone Deacetylase Inhibitors Using Pharmacophore Query and Docking Study
por: Haji Agha Bozorgi, Atefeh, et al.
Publicado: (2014)

Chemical Composition of Pinus roxburghii Bark Volatile Oil and Validation of Its Anti-Inflammatory Activity Using Molecular Modelling and Bleomycin-Induced Inflammation in Albino Mice
por: Labib, Rola M., et al.
Publicado: (2017)

Integration of Andrographis paniculata as Potential Medicinal Plant in Chir Pine (Pinus roxburghii Sarg.) Plantation of North-Western Himalaya
por: Sanwal, Chandra Shekher, et al.
Publicado: (2016)

Secondary metabolites isolated from Pinus roxburghii and interpretation of their cannabinoid and opioid binding properties by virtual screening and in vitro studies
por: Labib, Rola M., et al.
Publicado: (2018)

Aboveground carbon of community-managed Chirpine (Pinus roxburghii Sarg.) forests of Nepal based on stand types and geographic aspects
por: Pariyar, Shiva, et al.
Publicado: (2019)

In Vitro and In Silico Protocols for the Assessment of Anti-Tick Compounds from Pinus roxburghii against Rhipicephalus (Boophilus) microplus Ticks
por: Ayub, Sana, et al.
Publicado: (2023)

Pharmacophore Modeling, Virtual Screening, and Molecular Docking Studies for Discovery of Novel Akt2 Inhibitors
por: Fei, Jia, et al.
Publicado: (2013)

Pharmacophore-Based Screening, Molecular Docking, and Dynamic Simulation of Fungal Metabolites as Inhibitors of Multi-Targets in Neurodegenerative Disorders
por: Iqbal, Danish, et al.
Publicado: (2023)

The discovery of potential acetylcholinesterase inhibitors: A combination of pharmacophore modeling, virtual screening, and molecular docking studies
por: Lu, Shin-Hua, et al.
Publicado: (2011)

Potent bace-1 inhibitor design using pharmacophore modeling, in silico screening and molecular docking studies
por: John, Shalini, et al.
Publicado: (2011)

Synthesis, antimicrobial activity, pharmacophore modeling and molecular docking studies of new pyrazole-dimedone hybrid architectures
por: Barakat, Assem, et al.
Publicado: (2018)

Molecular Docking and 3D-Pharmacophore Modeling to Study the Interactions of Chalcone Derivatives with Estrogen Receptor Alpha
por: Muchtaridi, Muchtaridi, et al.
Publicado: (2017)

Combining docking with pharmacophore filtering for improved virtual screening
por: Peach, Megan L, et al.
Publicado: (2009)

Genetic Diversity of Pinus Roxburghii Sarg. Collected from Different Himalayan Regions of India Assessed by Random Amplified Polymorphic DNA Analysis
por: Sinha, Dwaipayan, et al.
Publicado: (2013)

Clinical Prevalence, Antibiogram Profiling and Gompertz Growth Kinetics of Resistant Staphylococcus epidermidis Treated with Nanoparticles of Rosin Extracted from Pinus roxburghii
por: Majeed, Zahid, et al.
Publicado: (2022)

In Silico Design of Human IMPDH Inhibitors Using Pharmacophore Mapping and Molecular Docking Approaches
por: Li, Rui-Juan, et al.
Publicado: (2015)

Discovery of Novel DPP-IV Inhibitors as Potential Candidates for the Treatment of Type 2 Diabetes Mellitus Predicted by 3D QSAR Pharmacophore Models, Molecular Docking and De Novo Evolution
por: Musoev, Azizullo, et al.
Publicado: (2019)

Total Synthesis and Pharmacological Investigation of Cordyheptapeptide A
por: Kumar, Suresh, et al.
Publicado: (2017)

Pharmacophore Modeling and Docking Studies on Some Nonpeptide-Based Caspase-3 Inhibitors
por: Sharma, Simant, et al.
Publicado: (2013)

Discovery of Novel Glucagon Receptor Antagonists Using Combined Pharmacophore Modeling and Docking
por: Jafari, Fataneh, et al.
Publicado: (2018)

Identification of Novel Src Inhibitors: Pharmacophore-Based Virtual Screening, Molecular Docking and Molecular Dynamics Simulations
por: Zhang, Yi, et al.
Publicado: (2020)

Reverse pharmacophore mapping and molecular docking studies for discovery of GTPase HRas as promising drug target for bis-pyrimidine derivatives
por: Kumar, Sanjiv, et al.
Publicado: (2018)

Ligand-based Pharmacophore Modeling, Virtual Screening and Molecular Docking Studies for Discovery of Potential Topoisomerase I Inhibitors
por: Pal, Sourav, et al.
Publicado: (2019)

Identification of Human Leukotriene A4 Hydrolase Inhibitors Using Structure-Based Pharmacophore Modeling and Molecular Docking
por: Audat, Suaad A., et al.
Publicado: (2020)

Pharmacophore modeling, in silico screening, molecular docking and molecular dynamics approaches for potential alpha-delta bungarotoxin-4 inhibitors discovery
por: Kumar, R. Barani, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_lam5p8ddf2hkff06asprljank7