2-[5-(2-Methyl­phen­yl)-3-(2-methyl­styryl)-4,5-di­hydro-1H-pyrazol-1-yl]-6-(thio­phen-2-yl)-4-(tri­fluoro­meth­yl)pyrimidine chloro­form monosolvate

In the crystal structure of the title compound, C(28)H(23)F(3)N(4)S·CHCl(3), the chloro­form solvate mol­ecules connect the pyrimidine mol­ecules into chains along [101] through weak C—H⋯N and C—H⋯Cl hydrogen-bond inter­actions. There are further connections between adjacent chains through F⋯Cl halo...

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Detalles Bibliográficos
Autores principales: Flores, Alex Fabiani Claro, Flores, Darlene Correia, Vicenti, Juliano Rosa de Menezes, Campos, Patrick Teixeira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2014
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120551/
https://www.ncbi.nlm.nih.gov/pubmed/25161574
http://dx.doi.org/10.1107/S160053681401321X
Descripción
Sumario:In the crystal structure of the title compound, C(28)H(23)F(3)N(4)S·CHCl(3), the chloro­form solvate mol­ecules connect the pyrimidine mol­ecules into chains along [101] through weak C—H⋯N and C—H⋯Cl hydrogen-bond inter­actions. There are further connections between adjacent chains through F⋯Cl halogen contacts of 3.185 (3) Å, with the –CF(3) group presenting a significant short F⋯F inter­chain distance of 2.712 (4) Å. The five-membered pyrazole ring is approximately planar (r.m.s. deviation = 0.050 Å). The pyrimidine ring makes dihedral angles of 84.15 (8) and 4.56 (8)° with the benzene rings.

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