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History of the discovery of a master locus producing piRNAs: the flamenco/COM locus in Drosophila melanogaster
The discovery of transposable elements (TEs) in the 1950s by B. McClintock implied the existence of cellular regulatory systems controlling TE activity. The discovery of flamenco (flam) an heterochromatic locus from Drosophila melanogaster and its ability to survey several TEs such as gypsy, ZAM, an...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120762/ https://www.ncbi.nlm.nih.gov/pubmed/25136352 http://dx.doi.org/10.3389/fgene.2014.00257 |
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author | Coline, Goriaux Théron, Emmanuelle Brasset, Emilie Vaury, Chantal |
author_facet | Coline, Goriaux Théron, Emmanuelle Brasset, Emilie Vaury, Chantal |
author_sort | Coline, Goriaux |
collection | PubMed |
description | The discovery of transposable elements (TEs) in the 1950s by B. McClintock implied the existence of cellular regulatory systems controlling TE activity. The discovery of flamenco (flam) an heterochromatic locus from Drosophila melanogaster and its ability to survey several TEs such as gypsy, ZAM, and Idefix contributed to peer deeply into the mechanisms of the genetic and epigenetic regulation of TEs. flam was the first cluster producing small RNAs to be discovered long before RNAi pathways were identified in 1998. As a result of the detailed genetic analyses performed by certain laboratories and of the sophisticated genetic tools they developed, this locus has played a major role in our understanding of piRNA mediated TE repression in animals. Here we review the first discovery of this locus and retrace decades of studies that led to our current understanding of the relationship between genomes and their TE targets. |
format | Online Article Text |
id | pubmed-4120762 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-41207622014-08-18 History of the discovery of a master locus producing piRNAs: the flamenco/COM locus in Drosophila melanogaster Coline, Goriaux Théron, Emmanuelle Brasset, Emilie Vaury, Chantal Front Genet Genetics The discovery of transposable elements (TEs) in the 1950s by B. McClintock implied the existence of cellular regulatory systems controlling TE activity. The discovery of flamenco (flam) an heterochromatic locus from Drosophila melanogaster and its ability to survey several TEs such as gypsy, ZAM, and Idefix contributed to peer deeply into the mechanisms of the genetic and epigenetic regulation of TEs. flam was the first cluster producing small RNAs to be discovered long before RNAi pathways were identified in 1998. As a result of the detailed genetic analyses performed by certain laboratories and of the sophisticated genetic tools they developed, this locus has played a major role in our understanding of piRNA mediated TE repression in animals. Here we review the first discovery of this locus and retrace decades of studies that led to our current understanding of the relationship between genomes and their TE targets. Frontiers Media S.A. 2014-08-04 /pmc/articles/PMC4120762/ /pubmed/25136352 http://dx.doi.org/10.3389/fgene.2014.00257 Text en Copyright © 2014 Goriaux, Théron, Brasset and Vaury. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Coline, Goriaux Théron, Emmanuelle Brasset, Emilie Vaury, Chantal History of the discovery of a master locus producing piRNAs: the flamenco/COM locus in Drosophila melanogaster |
title | History of the discovery of a master locus producing piRNAs: the flamenco/COM locus in Drosophila melanogaster |
title_full | History of the discovery of a master locus producing piRNAs: the flamenco/COM locus in Drosophila melanogaster |
title_fullStr | History of the discovery of a master locus producing piRNAs: the flamenco/COM locus in Drosophila melanogaster |
title_full_unstemmed | History of the discovery of a master locus producing piRNAs: the flamenco/COM locus in Drosophila melanogaster |
title_short | History of the discovery of a master locus producing piRNAs: the flamenco/COM locus in Drosophila melanogaster |
title_sort | history of the discovery of a master locus producing pirnas: the flamenco/com locus in drosophila melanogaster |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120762/ https://www.ncbi.nlm.nih.gov/pubmed/25136352 http://dx.doi.org/10.3389/fgene.2014.00257 |
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