Cargando…

History of the discovery of a master locus producing piRNAs: the flamenco/COM locus in Drosophila melanogaster

The discovery of transposable elements (TEs) in the 1950s by B. McClintock implied the existence of cellular regulatory systems controlling TE activity. The discovery of flamenco (flam) an heterochromatic locus from Drosophila melanogaster and its ability to survey several TEs such as gypsy, ZAM, an...

Descripción completa

Detalles Bibliográficos
Autores principales: Coline, Goriaux, Théron, Emmanuelle, Brasset, Emilie, Vaury, Chantal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120762/
https://www.ncbi.nlm.nih.gov/pubmed/25136352
http://dx.doi.org/10.3389/fgene.2014.00257
_version_ 1782329140868808704
author Coline, Goriaux
Théron, Emmanuelle
Brasset, Emilie
Vaury, Chantal
author_facet Coline, Goriaux
Théron, Emmanuelle
Brasset, Emilie
Vaury, Chantal
author_sort Coline, Goriaux
collection PubMed
description The discovery of transposable elements (TEs) in the 1950s by B. McClintock implied the existence of cellular regulatory systems controlling TE activity. The discovery of flamenco (flam) an heterochromatic locus from Drosophila melanogaster and its ability to survey several TEs such as gypsy, ZAM, and Idefix contributed to peer deeply into the mechanisms of the genetic and epigenetic regulation of TEs. flam was the first cluster producing small RNAs to be discovered long before RNAi pathways were identified in 1998. As a result of the detailed genetic analyses performed by certain laboratories and of the sophisticated genetic tools they developed, this locus has played a major role in our understanding of piRNA mediated TE repression in animals. Here we review the first discovery of this locus and retrace decades of studies that led to our current understanding of the relationship between genomes and their TE targets.
format Online
Article
Text
id pubmed-4120762
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-41207622014-08-18 History of the discovery of a master locus producing piRNAs: the flamenco/COM locus in Drosophila melanogaster Coline, Goriaux Théron, Emmanuelle Brasset, Emilie Vaury, Chantal Front Genet Genetics The discovery of transposable elements (TEs) in the 1950s by B. McClintock implied the existence of cellular regulatory systems controlling TE activity. The discovery of flamenco (flam) an heterochromatic locus from Drosophila melanogaster and its ability to survey several TEs such as gypsy, ZAM, and Idefix contributed to peer deeply into the mechanisms of the genetic and epigenetic regulation of TEs. flam was the first cluster producing small RNAs to be discovered long before RNAi pathways were identified in 1998. As a result of the detailed genetic analyses performed by certain laboratories and of the sophisticated genetic tools they developed, this locus has played a major role in our understanding of piRNA mediated TE repression in animals. Here we review the first discovery of this locus and retrace decades of studies that led to our current understanding of the relationship between genomes and their TE targets. Frontiers Media S.A. 2014-08-04 /pmc/articles/PMC4120762/ /pubmed/25136352 http://dx.doi.org/10.3389/fgene.2014.00257 Text en Copyright © 2014 Goriaux, Théron, Brasset and Vaury. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Coline, Goriaux
Théron, Emmanuelle
Brasset, Emilie
Vaury, Chantal
History of the discovery of a master locus producing piRNAs: the flamenco/COM locus in Drosophila melanogaster
title History of the discovery of a master locus producing piRNAs: the flamenco/COM locus in Drosophila melanogaster
title_full History of the discovery of a master locus producing piRNAs: the flamenco/COM locus in Drosophila melanogaster
title_fullStr History of the discovery of a master locus producing piRNAs: the flamenco/COM locus in Drosophila melanogaster
title_full_unstemmed History of the discovery of a master locus producing piRNAs: the flamenco/COM locus in Drosophila melanogaster
title_short History of the discovery of a master locus producing piRNAs: the flamenco/COM locus in Drosophila melanogaster
title_sort history of the discovery of a master locus producing pirnas: the flamenco/com locus in drosophila melanogaster
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120762/
https://www.ncbi.nlm.nih.gov/pubmed/25136352
http://dx.doi.org/10.3389/fgene.2014.00257
work_keys_str_mv AT colinegoriaux historyofthediscoveryofamasterlocusproducingpirnastheflamencocomlocusindrosophilamelanogaster
AT theronemmanuelle historyofthediscoveryofamasterlocusproducingpirnastheflamencocomlocusindrosophilamelanogaster
AT brassetemilie historyofthediscoveryofamasterlocusproducingpirnastheflamencocomlocusindrosophilamelanogaster
AT vaurychantal historyofthediscoveryofamasterlocusproducingpirnastheflamencocomlocusindrosophilamelanogaster