Response to Rituximab in a Case of Lupus Associated Digital Ischemia

We report the case of a 38-year-old female patient with systemic lupus erythematosus (SLE) and Jaccoud arthritis (JA) that sequentially developed digital ischemic lesions of the hands. In spite of follow-up treatment with glucocorticoids, immunosuppressant, antiaggregant, and potent vasodilatator ag...

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Autores principales: Küçükşahin, Orhan, Düzgün, Nurşen, Okoh, Alexis K., Kulahçioglu, Emre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120793/
https://www.ncbi.nlm.nih.gov/pubmed/25114828
http://dx.doi.org/10.1155/2014/763608
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author Küçükşahin, Orhan
Düzgün, Nurşen
Okoh, Alexis K.
Kulahçioglu, Emre
author_facet Küçükşahin, Orhan
Düzgün, Nurşen
Okoh, Alexis K.
Kulahçioglu, Emre
author_sort Küçükşahin, Orhan
collection PubMed
description We report the case of a 38-year-old female patient with systemic lupus erythematosus (SLE) and Jaccoud arthritis (JA) that sequentially developed digital ischemic lesions of the hands. In spite of follow-up treatment with glucocorticoids, immunosuppressant, antiaggregant, and potent vasodilatator agents, a serious progression to digital gangrene over a one-month period was observed. Surprisingly, her nonhealing digital lesions improved after two cycles of rituximab (RTX) administration.
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spelling pubmed-41207932014-08-11 Response to Rituximab in a Case of Lupus Associated Digital Ischemia Küçükşahin, Orhan Düzgün, Nurşen Okoh, Alexis K. Kulahçioglu, Emre Case Rep Rheumatol Case Report We report the case of a 38-year-old female patient with systemic lupus erythematosus (SLE) and Jaccoud arthritis (JA) that sequentially developed digital ischemic lesions of the hands. In spite of follow-up treatment with glucocorticoids, immunosuppressant, antiaggregant, and potent vasodilatator agents, a serious progression to digital gangrene over a one-month period was observed. Surprisingly, her nonhealing digital lesions improved after two cycles of rituximab (RTX) administration. Hindawi Publishing Corporation 2014 2014-07-09 /pmc/articles/PMC4120793/ /pubmed/25114828 http://dx.doi.org/10.1155/2014/763608 Text en Copyright © 2014 Orhan Küçükşahin et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Küçükşahin, Orhan
Düzgün, Nurşen
Okoh, Alexis K.
Kulahçioglu, Emre
Response to Rituximab in a Case of Lupus Associated Digital Ischemia
title Response to Rituximab in a Case of Lupus Associated Digital Ischemia
title_full Response to Rituximab in a Case of Lupus Associated Digital Ischemia
title_fullStr Response to Rituximab in a Case of Lupus Associated Digital Ischemia
title_full_unstemmed Response to Rituximab in a Case of Lupus Associated Digital Ischemia
title_short Response to Rituximab in a Case of Lupus Associated Digital Ischemia
title_sort response to rituximab in a case of lupus associated digital ischemia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120793/
https://www.ncbi.nlm.nih.gov/pubmed/25114828
http://dx.doi.org/10.1155/2014/763608
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AT kulahciogluemre responsetorituximabinacaseoflupusassociateddigitalischemia

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