Selenopeptide Transamidation and Metathesis

[Image: see text] Selenopeptides can be transamidated by cysteinyl peptides in water using mild conditions (pH 5.5, 37 °C) in the presence of an arylthiol catalyst. Similar conditions also catalyze the metathesis of selenopeptides. The usefulness of the selenophosphine derived from TCEP (TCEP=Se) fo...

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Autores principales: Ollivier, Nathalie, Blanpain, Annick, Boll, Emmanuelle, Raibaut, Laurent, Drobecq, Hervé, Melnyk, Oleg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120982/
https://www.ncbi.nlm.nih.gov/pubmed/25017723
http://dx.doi.org/10.1021/ol501866j
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author Ollivier, Nathalie
Blanpain, Annick
Boll, Emmanuelle
Raibaut, Laurent
Drobecq, Hervé
Melnyk, Oleg
author_facet Ollivier, Nathalie
Blanpain, Annick
Boll, Emmanuelle
Raibaut, Laurent
Drobecq, Hervé
Melnyk, Oleg
author_sort Ollivier, Nathalie
collection PubMed
description [Image: see text] Selenopeptides can be transamidated by cysteinyl peptides in water using mild conditions (pH 5.5, 37 °C) in the presence of an arylthiol catalyst. Similar conditions also catalyze the metathesis of selenopeptides. The usefulness of the selenophosphine derived from TCEP (TCEP=Se) for inhibiting the TCEP-induced deselenization of selenocysteine residue is also reported.
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spelling pubmed-41209822015-07-14 Selenopeptide Transamidation and Metathesis Ollivier, Nathalie Blanpain, Annick Boll, Emmanuelle Raibaut, Laurent Drobecq, Hervé Melnyk, Oleg Org Lett [Image: see text] Selenopeptides can be transamidated by cysteinyl peptides in water using mild conditions (pH 5.5, 37 °C) in the presence of an arylthiol catalyst. Similar conditions also catalyze the metathesis of selenopeptides. The usefulness of the selenophosphine derived from TCEP (TCEP=Se) for inhibiting the TCEP-induced deselenization of selenocysteine residue is also reported. American Chemical Society 2014-07-14 2014-08-01 /pmc/articles/PMC4120982/ /pubmed/25017723 http://dx.doi.org/10.1021/ol501866j Text en Copyright © 2014 American Chemical Society Terms of Use (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html)
spellingShingle Ollivier, Nathalie
Blanpain, Annick
Boll, Emmanuelle
Raibaut, Laurent
Drobecq, Hervé
Melnyk, Oleg
Selenopeptide Transamidation and Metathesis
title Selenopeptide Transamidation and Metathesis
title_full Selenopeptide Transamidation and Metathesis
title_fullStr Selenopeptide Transamidation and Metathesis
title_full_unstemmed Selenopeptide Transamidation and Metathesis
title_short Selenopeptide Transamidation and Metathesis
title_sort selenopeptide transamidation and metathesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120982/
https://www.ncbi.nlm.nih.gov/pubmed/25017723
http://dx.doi.org/10.1021/ol501866j
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AT raibautlaurent selenopeptidetransamidationandmetathesis
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