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Total Synthesis of Tetrahydrolipstatin and Stereoisomers via a Highly Regio- and Diastereoselective Carbonylation of Epoxyhomoallylic Alcohols

[Image: see text] A concise enantioselective synthesis of tetrahydrolipstatin (THL) and seven stereoisomers has been achieved. The synthesis of THL was accomplished in 10 steps and 31% overall yield from an achiral ynone. Key to the success of the approach is the use of a bimetallic [Lewis acid](+)[...

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Detalles Bibliográficos
Autores principales:	Mulzer, Michael, Tiegs, Brandon J., Wang, Yanping, Coates, Geoffrey W., O’Doherty, George A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120994/ https://www.ncbi.nlm.nih.gov/pubmed/25004122 http://dx.doi.org/10.1021/ja505639u

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