Rational Design of CXCR4 Specific Antibodies with Elongated CDRs

[Image: see text] The bovine antibody (BLV1H12) which has an ultralong heavy chain complementarity determining region 3 (CDRH3) provides a novel scaffold for antibody engineering. By substituting the extended CDRH3 of BLV1H12 with modified CXCR4 binding peptides that adopt a β-hairpin conformation,...

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Detalles Bibliográficos
Autores principales: Liu, Tao, Liu, Yan, Wang, Ying, Hull, Mitchell, Schultz, Peter G., Wang, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120998/
https://www.ncbi.nlm.nih.gov/pubmed/25041362
http://dx.doi.org/10.1021/ja5042447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120998/
https://www.ncbi.nlm.nih.gov/pubmed/25041362
http://dx.doi.org/10.1021/ja5042447

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