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Unique Pattern of Component Gene Disruption in the NRF2 Inhibitor KEAP1/CUL3/RBX1 E3-Ubiquitin Ligase Complex in Serous Ovarian Cancer
The NFE2-related factor 2 (NRF2) pathway is critical to initiate responses to oxidative stress; however, constitutive activation occurs in different cancer types, including serous ovarian carcinomas (OVCA). The KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex is a regulator of NRF2 levels. Hence, we inve...
Autores principales: | Martinez, Victor D., Vucic, Emily A., Thu, Kelsie L., Pikor, Larissa A., Hubaux, Roland, Lam, Wan L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121105/ https://www.ncbi.nlm.nih.gov/pubmed/25114896 http://dx.doi.org/10.1155/2014/159459 |
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