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Decitabine Suspends Human CD34(+) Cell Differentiation and Proliferation during Lentiviral Transduction
Efficient ex vivo transduction of hematopoietic stem cells (HSCs) is encumbered by differentiation which reduces engraftment. We hypothesized that inhibiting DNA methyltransferase with decitabine would block differentiation of transduced CD34(+) cells under cytokine stimulation and thus improve tran...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121241/ https://www.ncbi.nlm.nih.gov/pubmed/25089909 http://dx.doi.org/10.1371/journal.pone.0104022 |