Cargando…

15-Deoxy-γ12,14-prostaglandin J2 Reduces Liver Impairment in a Model of ConA-Induced Acute Hepatic Inflammation by Activation of PPARγ and Reduction in NF-κB Activity

Objective. 15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) reduces inflammation and has been identified as an anti-inflammatory prostaglandin in numerous animal models. In this study, we investigated both effects of 15d-PGJ2 and its protection mechanism in concanavalin A- (ConA-) induced autoimmune hepa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Kan, Li, Jingjing, Wang, Junshan, Xia, Yujing, Dai, Weiqi, Wang, Fan, Shen, Miao, Cheng, Ping, Zhang, Yan, Wang, Chengfen, Yang, Jing, Zhu, Rong, Zhang, Huawei, Zheng, Yuanyuan, Lu, Jie, Fan, Zhuoyi, Zhou, Yingqun, Guo, Chuanyong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121249/ https://www.ncbi.nlm.nih.gov/pubmed/25120564 http://dx.doi.org/10.1155/2014/215631

Ejemplares similares

Erratum to “15-Deoxy-γ12,14-prostaglandin J2 Reduces Liver Impairment in a Model of ConA-Induced Acute Hepatic Inflammation by Activation of PPARγ and Reduction in NF-κB Activity”
por: Chen, Kan, et al.
Publicado: (2014)

15-Deoxy-∆-(12,14)-Prostaglandin J2 (15d-PGJ2), an Endogenous Ligand of PPAR-γ: Function and Mechanism
por: Li, Jingjing, et al.
Publicado: (2019)

Protective Effects of Astaxanthin on ConA-Induced Autoimmune Hepatitis by the JNK/p-JNK Pathway-Mediated Inhibition of Autophagy and Apoptosis
por: Li, Jingjing, et al.
Publicado: (2015)

Cytotoxicity of 15-Deoxy-Δ(12,14)-prostaglandin J(2) through PPARγ-independent Pathway and the Involvement of the JNK and Akt Pathway in Renal Cell Carcinoma
por: Fujita, Megumi, et al.
Publicado: (2012)

15-Deoxy-Δ(12,14)-prostaglandin J(2) as a potential regulator of bone metabolism via PPARγ-dependent and independent pathways: a review
por: Xiong, Zhencheng, et al.
Publicado: (2019)

Contrasting effects of peroxisome-proliferator-activated receptor (PPAR)γ agonists on membrane-associated prostaglandin E(2 )synthase-1 in IL-1β-stimulated rat chondrocytes: evidence for PPARγ-independent inhibition by 15-deoxy-Δ(12,14)prostaglandin J(2)
por: Bianchi, Arnaud, et al.
Publicado: (2005)

The Protective Effects of Levo-Tetrahydropalmatine on ConA-Induced Liver Injury Are via TRAF6/JNK Signaling
por: Yu, Qiang, et al.
Publicado: (2018)

The PPAR-γ Agonist 15-Deoxy-Δ (12,14)-Prostaglandin J(2) Attenuates Microglial Production of IL-12 Family Cytokines: Potential Relevance to Alzheimer's Disease
por: Xu, Jihong, et al.
Publicado: (2008)

The Eicosapentaenoic Acid Metabolite 15-Deoxy-δ(12,14)-Prostaglandin J(3) Increases Adiponectin Secretion by Adipocytes Partly via a PPARγ-Dependent Mechanism
por: Lefils-Lacourtablaise, Jennifer, et al.
Publicado: (2013)

Pretreatment with Fucoidan from Fucus vesiculosus Protected against ConA-Induced Acute Liver Injury by Inhibiting Both Intrinsic and Extrinsic Apoptosis
por: Li, Jingjing, et al.
Publicado: (2016)

Diagnostic Performance of Des-γ-carboxy Prothrombin for Hepatocellular Carcinoma: A Meta-Analysis
por: Zhu, Rong, et al.
Publicado: (2014)

ERK-1/-2 and p38 Kinase Oppositely Regulate 15-deoxy-Δ(12,14)-prostaglandinJ(2)-Induced PPAR-γ Activation That Mediates Dedifferentiation But Not Cyclooxygenase-2 Expression in Articular Chondrocytes
por: Yoon, Eun-Kyung, et al.
Publicado: (2007)

15-deoxy-Δ(12,14)-prostaglandin J(2) in neurodegenerative diseases and cancers
por: Yagami, Tatsurou, et al.
Publicado: (2017)

Prostaglandins as PPARγ Modulators in Adipogenesis
por: Fujimori, Ko
Publicado: (2012)

15-Deoxy-Δ(12,14)-ProstaglandinJ2 Regulates Dedifferentiation through Peroxisome Proliferator-Activated Receptor-γ-Dependent Pathway but Not COX-2 Expression in Articular Chondrocytes
por: Lee, Ji-Hye, et al.
Publicado: (2007)

15-Deoxy-△(12,14)-Prostaglandin J(2) Promotes Resolution of Experimentally Induced Colitis
por: Kim, Wonki, et al.
Publicado: (2021)

Inhibitive effects of 15-deoxy-Δ(12),(14)-prostaglandin J(2) on hepatoma-cell proliferation through reactive oxygen species-mediated apoptosis
por: Chen, Kan, et al.
Publicado: (2015)

Protective Effects of N-Acetylcysteine in Concanavalin A-Induced Hepatitis in Mice
por: Wang, Chengfen, et al.
Publicado: (2015)

15-deoxy-delta(12,14)-prostaglandin J(2 )induces apoptosis in human articular chondrocytes
por: Masuko-Hongo, K, et al.
Publicado: (2003)

Rac1 modification by an electrophilic 15-deoxy Δ(12,14)-prostaglandin J(2) analog
por: Wall, S.B., et al.
Publicado: (2015)

Bergenin Attenuates Hepatic Fibrosis by Regulating Autophagy Mediated by the PPAR-γ/TGF-β Pathway
por: Xia, Yujing, et al.
Publicado: (2020)

K-ras Mutational Status in Cytohistological Tissue as a Molecular Marker for the Diagnosis of Pancreatic Cancer: A Systematic Review and Meta-Analysis
por: Yang, Jing, et al.
Publicado: (2014)

N-Acetylcysteine Attenuates Ischemia-Reperfusion-Induced Apoptosis and Autophagy in Mouse Liver via Regulation of the ROS/JNK/Bcl-2 Pathway
por: Wang, Chengfen, et al.
Publicado: (2014)

Hydrogen sulfide, a potential novel drug, attenuates concanavalin A-induced hepatitis
por: Cheng, Ping, et al.
Publicado: (2014)

Golgi protein 73 as a biomarker for hepatocellular carcinoma: A diagnostic meta-analysis
por: YANG, JING, et al.
Publicado: (2015)

Feedback Control of the Arachidonate Cascade in Osteoblastic Cells by 15-deoxy-Δ(12,14)-Prostaglandin J(2)
por: Ishino, Hidetaka, et al.
Publicado: (2008)

The Effects of Co-Treatment of 9-cis-Retinoic Acid and 15-Deoxy-Δ (12,14)-prostaglandin J2 on Microglial Activation
por: Hsu, Pei-Chien, et al.
Publicado: (2011)

Synergistic effects of 15-deoxy Δ(12,14)-prostaglandin J(2) on the anti-tumor activity of doxorubicin in renal cell carcinoma
por: Yamamoto, Yasuhiro, et al.
Publicado: (2016)

15-deoxy-delta12,14-prostaglandin J2 attenuates endothelial-monocyte interaction: implication for inflammatory diseases
por: Prasad, Ratna, et al.
Publicado: (2008)

Proteomic Identification of Protein Targets for 15-Deoxy-Δ(12,14)-Prostaglandin J(2) in Neuronal Plasma Membrane
por: Yamamoto, Yasuhiro, et al.
Publicado: (2011)

15-Deoxy-Δ(12,14)-Prostaglandin J(2) Inhibits Macrophage Colonization by Salmonella enterica Serovar Typhimurium
por: Buckner, Michelle M. C., et al.
Publicado: (2013)

15-Deoxy-Δ(12,14)-prostaglandin J2 promotes phosphorylation of eukaryotic initiation factor 2α and activates the integrated stress response
por: Tauber, Devin, et al.
Publicado: (2019)

15-Deoxy-Δ(12,14)-prostaglandin J(2) Induces Epithelial-to-mesenchymal Transition in Human Breast Cancer Cells and Promotes Fibroblast Activation
por: Choi, Jeehye, et al.
Publicado: (2020)

15-Deoxy-Δ(12,14) Prostaglandin J(2) Reduces the Formation of Atherosclerotic Lesions in Apolipoprotein E Knockout Mice
por: Seno, Takahiro, et al.
Publicado: (2011)

Correction: Proteomic Identification of Protein Targets for 15-Deoxy-Δ(12,14)-Prostaglandin J(2) in Neuronal Plasma Membrane
por: Yamamoto, Yasuhiro, et al.
Publicado: (2011)

15-Deoxy-Delta-12,14-Prostaglandin J(2) Inhibits Lung Inflammation and Remodeling in Distinct Murine Models of Asthma
por: Coutinho, Diego S., et al.
Publicado: (2017)

Portulaca Extract Attenuates Development of Dextran Sulfate Sodium Induced Colitis in Mice through Activation of PPARγ
por: Kong, Rui, et al.
Publicado: (2018)

Changes in the Th1 : Th2 Cytokine Bias in Pregnancy and the Effects of the Anti-Inflammatory Cyclopentenone Prostaglandin 15-Deoxy-Δ(12,14)-Prostaglandin J(2)
por: Sykes, Lynne, et al.
Publicado: (2012)

15-Deoxy-Δ(12,14)-prostaglandin J(2) Induces Apoptosis and Upregulates SOCS3 in Human Thyroid Cancer Cells
por: Trindade-da-Silva, Carlos Antônio, et al.
Publicado: (2016)

15-Deoxy-Δ(12,14)-Prostaglandin J(2) Modifies Components of the Proteasome and Inhibits Inflammatory Responses in Human Endothelial Cells
por: Marcone, Simone, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_ma5ehps0dqs2rtj4hole527u3c