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Low Levels of the Reverse Transactivator Fail to Induce Target Transgene Expression in Vascular Smooth Muscle Cells

Hutchinson-Gilford progeria syndrome (HGPS) is a genetic disease with multiple features that are suggestive of premature aging. Most patients with HGPS carry a mutation on one of their copies of the LMNA gene. The LMNA gene encodes the lamin A and lamin C proteins, which are the major proteins of th...

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Detalles Bibliográficos
Autores principales: Viceconte, Nikenza, McKenna, Tomás, Eriksson, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121313/
https://www.ncbi.nlm.nih.gov/pubmed/25090270
http://dx.doi.org/10.1371/journal.pone.0104098