Location, location, location: CD103 demarcates intraepithelial, prognostically favorable CD8(+) tumor-infiltrating lymphocytes in ovarian cancer

Although high levels of tumor-infiltrating lymphocytes (TILs) generally correlate with good prognosis in high-grade serous ovarian cancer (HGSC) patients, little is known about the phenotype or specificity of these cells. We have recently demonstrated that TIL expressing the intra-epithelial lymphoc...

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Autores principales: Webb, John R, Milne, Katy, Nelson, Brad H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121334/
https://www.ncbi.nlm.nih.gov/pubmed/25101220
http://dx.doi.org/10.4161/onci.27668
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author Webb, John R
Milne, Katy
Nelson, Brad H
author_facet Webb, John R
Milne, Katy
Nelson, Brad H
author_sort Webb, John R
collection PubMed
description Although high levels of tumor-infiltrating lymphocytes (TILs) generally correlate with good prognosis in high-grade serous ovarian cancer (HGSC) patients, little is known about the phenotype or specificity of these cells. We have recently demonstrated that TIL expressing the intra-epithelial lymphocyte marker CD103 (official name, integrin α(E), ITGAE) abundantly infiltrate HGSCs, strongly correlating with increased disease-specific survival.
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spelling pubmed-41213342014-08-06 Location, location, location: CD103 demarcates intraepithelial, prognostically favorable CD8(+) tumor-infiltrating lymphocytes in ovarian cancer Webb, John R Milne, Katy Nelson, Brad H Oncoimmunology Author's View Although high levels of tumor-infiltrating lymphocytes (TILs) generally correlate with good prognosis in high-grade serous ovarian cancer (HGSC) patients, little is known about the phenotype or specificity of these cells. We have recently demonstrated that TIL expressing the intra-epithelial lymphocyte marker CD103 (official name, integrin α(E), ITGAE) abundantly infiltrate HGSCs, strongly correlating with increased disease-specific survival. Landes Bioscience 2014-01-10 /pmc/articles/PMC4121334/ /pubmed/25101220 http://dx.doi.org/10.4161/onci.27668 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Webb, John R
Milne, Katy
Nelson, Brad H
Location, location, location: CD103 demarcates intraepithelial, prognostically favorable CD8(+) tumor-infiltrating lymphocytes in ovarian cancer
title Location, location, location: CD103 demarcates intraepithelial, prognostically favorable CD8(+) tumor-infiltrating lymphocytes in ovarian cancer
title_full Location, location, location: CD103 demarcates intraepithelial, prognostically favorable CD8(+) tumor-infiltrating lymphocytes in ovarian cancer
title_fullStr Location, location, location: CD103 demarcates intraepithelial, prognostically favorable CD8(+) tumor-infiltrating lymphocytes in ovarian cancer
title_full_unstemmed Location, location, location: CD103 demarcates intraepithelial, prognostically favorable CD8(+) tumor-infiltrating lymphocytes in ovarian cancer
title_short Location, location, location: CD103 demarcates intraepithelial, prognostically favorable CD8(+) tumor-infiltrating lymphocytes in ovarian cancer
title_sort location, location, location: cd103 demarcates intraepithelial, prognostically favorable cd8(+) tumor-infiltrating lymphocytes in ovarian cancer
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121334/
https://www.ncbi.nlm.nih.gov/pubmed/25101220
http://dx.doi.org/10.4161/onci.27668
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AT nelsonbradh locationlocationlocationcd103demarcatesintraepithelialprognosticallyfavorablecd8tumorinfiltratinglymphocytesinovariancancer

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