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Interleukin-6, but not the interleukin-6 receptor plays a role in recovery from dextran sodium sulfate-induced colitis

Interleukin (IL)-6-deficient, but not IL-6 receptor (IL-6R)-deficient mice present with a delayed skin wound healing phenotype. Since IL-6 solely signals via the IL-6R and glycoprotein 130 (gp130), Il-6r-deficient mice are expected to exhibit a similar phenotype as Il-6-deficient mice. However, p28...

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Autores principales: SOMMER, JAN, ENGELOWSKI, ERIKA, BARAN, PAUL, GARBERS, CHRISTOPH, FLOSS, DOREEN M., SCHELLER, JÜRGEN
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121342/
https://www.ncbi.nlm.nih.gov/pubmed/24993179
http://dx.doi.org/10.3892/ijmm.2014.1825
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author SOMMER, JAN
ENGELOWSKI, ERIKA
BARAN, PAUL
GARBERS, CHRISTOPH
FLOSS, DOREEN M.
SCHELLER, JÜRGEN
author_facet SOMMER, JAN
ENGELOWSKI, ERIKA
BARAN, PAUL
GARBERS, CHRISTOPH
FLOSS, DOREEN M.
SCHELLER, JÜRGEN
author_sort SOMMER, JAN
collection PubMed
description Interleukin (IL)-6-deficient, but not IL-6 receptor (IL-6R)-deficient mice present with a delayed skin wound healing phenotype. Since IL-6 solely signals via the IL-6R and glycoprotein 130 (gp130), Il-6r-deficient mice are expected to exhibit a similar phenotype as Il-6-deficient mice. However, p28 (IL-30) and ciliary neurotrophic factor (CNTF) have been identified as additional low-affinity ligands of the IL-6R/gp130/LIFR complex. IL-6 plays an inflammatory and regenerative role in inflammatory bowel disease (IBD). In the present study, we compared Il-6r-deficient mice with mice treated with neutralizing IL-6 monoclonal antibody (mAb) in a model of dextran sodium sulfate (DSS)-induced colitis. Our results, in agreement with those of previous reports, demonstrated that IL-6 mAbs slightly attenuated DSS-induced colitis during the regeneration phase. Il-6r-deficient mice and mice with tissue-specific deletion of the Il-6r in the myeloid cell lineage (LysMCre) with acute and chronic DSS-induced colitis were, however, indistinguishable from wild-type mice. Our data suggest that IL-6 and IL-6R have an additional role in colitis, apart from the IL-6/IL-6R classic and trans-signaling.
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spelling pubmed-41213422014-08-12 Interleukin-6, but not the interleukin-6 receptor plays a role in recovery from dextran sodium sulfate-induced colitis SOMMER, JAN ENGELOWSKI, ERIKA BARAN, PAUL GARBERS, CHRISTOPH FLOSS, DOREEN M. SCHELLER, JÜRGEN Int J Mol Med Articles Interleukin (IL)-6-deficient, but not IL-6 receptor (IL-6R)-deficient mice present with a delayed skin wound healing phenotype. Since IL-6 solely signals via the IL-6R and glycoprotein 130 (gp130), Il-6r-deficient mice are expected to exhibit a similar phenotype as Il-6-deficient mice. However, p28 (IL-30) and ciliary neurotrophic factor (CNTF) have been identified as additional low-affinity ligands of the IL-6R/gp130/LIFR complex. IL-6 plays an inflammatory and regenerative role in inflammatory bowel disease (IBD). In the present study, we compared Il-6r-deficient mice with mice treated with neutralizing IL-6 monoclonal antibody (mAb) in a model of dextran sodium sulfate (DSS)-induced colitis. Our results, in agreement with those of previous reports, demonstrated that IL-6 mAbs slightly attenuated DSS-induced colitis during the regeneration phase. Il-6r-deficient mice and mice with tissue-specific deletion of the Il-6r in the myeloid cell lineage (LysMCre) with acute and chronic DSS-induced colitis were, however, indistinguishable from wild-type mice. Our data suggest that IL-6 and IL-6R have an additional role in colitis, apart from the IL-6/IL-6R classic and trans-signaling. D.A. Spandidos 2014-09 2014-06-27 /pmc/articles/PMC4121342/ /pubmed/24993179 http://dx.doi.org/10.3892/ijmm.2014.1825 Text en Copyright © 2014, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
SOMMER, JAN
ENGELOWSKI, ERIKA
BARAN, PAUL
GARBERS, CHRISTOPH
FLOSS, DOREEN M.
SCHELLER, JÜRGEN
Interleukin-6, but not the interleukin-6 receptor plays a role in recovery from dextran sodium sulfate-induced colitis
title Interleukin-6, but not the interleukin-6 receptor plays a role in recovery from dextran sodium sulfate-induced colitis
title_full Interleukin-6, but not the interleukin-6 receptor plays a role in recovery from dextran sodium sulfate-induced colitis
title_fullStr Interleukin-6, but not the interleukin-6 receptor plays a role in recovery from dextran sodium sulfate-induced colitis
title_full_unstemmed Interleukin-6, but not the interleukin-6 receptor plays a role in recovery from dextran sodium sulfate-induced colitis
title_short Interleukin-6, but not the interleukin-6 receptor plays a role in recovery from dextran sodium sulfate-induced colitis
title_sort interleukin-6, but not the interleukin-6 receptor plays a role in recovery from dextran sodium sulfate-induced colitis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121342/
https://www.ncbi.nlm.nih.gov/pubmed/24993179
http://dx.doi.org/10.3892/ijmm.2014.1825
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