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The effects of different loading doses of dexmedetomidine on sedation

BACKGROUND: Dexmedetomidine is a useful sedative drug with various uses. We designed this study to investigate the clinical effects and complications of different loading doses, 0.5 and 1.0 µg/kg. METHODS: Forty six patients, of American Society of Anesthesiologists physical status I and II, who req...

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Autores principales: Sim, Jae Hwan, Yu, Hyun Jeong, Kim, Sang Tae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Anesthesiologists 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121500/
https://www.ncbi.nlm.nih.gov/pubmed/25097732
http://dx.doi.org/10.4097/kjae.2014.67.1.8
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author Sim, Jae Hwan
Yu, Hyun Jeong
Kim, Sang Tae
author_facet Sim, Jae Hwan
Yu, Hyun Jeong
Kim, Sang Tae
author_sort Sim, Jae Hwan
collection PubMed
description BACKGROUND: Dexmedetomidine is a useful sedative drug with various uses. We designed this study to investigate the clinical effects and complications of different loading doses, 0.5 and 1.0 µg/kg. METHODS: Forty six patients, of American Society of Anesthesiologists physical status I and II, who required elective and emergency operation under spinal anesthesia were randomly assigned to group L or group H. Group L received a loading dose of 0.5 µg/kg for 10 minutes while group H received 1.0 µg/kg. Bispectral index (BIS), systolic blood pressure, heart rate, and Ramsay score were recorded at T(0) (before loading), T(L) (just after loading) and T(10, 20, 30) (10, 20, 30 minutes after T(L)). Complications, drug use, lowest BIS and time to reach BIS 80 after termination of dexmedetomidine were recorded during this study. RESULTS: In group H, BIS value decreased significantly after T(L) compared to the baseline (T(0)), while in group L after T(10). Between two groups, BIS values showed a significant differences only at T(10), BIS of group H was lower than that of group L. Ramsay score showed no significant differences except in T(L); the score of group L was significantly lower than that of group H. Other vital signs and complications showed a minimal differences between two groups. CONCLUSIONS: Higher loading dose (1.0 µg/kg) of dexmedetomidine can lead to faster sedation without any severe complications.
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spelling pubmed-41215002014-08-05 The effects of different loading doses of dexmedetomidine on sedation Sim, Jae Hwan Yu, Hyun Jeong Kim, Sang Tae Korean J Anesthesiol Clinical Research Article BACKGROUND: Dexmedetomidine is a useful sedative drug with various uses. We designed this study to investigate the clinical effects and complications of different loading doses, 0.5 and 1.0 µg/kg. METHODS: Forty six patients, of American Society of Anesthesiologists physical status I and II, who required elective and emergency operation under spinal anesthesia were randomly assigned to group L or group H. Group L received a loading dose of 0.5 µg/kg for 10 minutes while group H received 1.0 µg/kg. Bispectral index (BIS), systolic blood pressure, heart rate, and Ramsay score were recorded at T(0) (before loading), T(L) (just after loading) and T(10, 20, 30) (10, 20, 30 minutes after T(L)). Complications, drug use, lowest BIS and time to reach BIS 80 after termination of dexmedetomidine were recorded during this study. RESULTS: In group H, BIS value decreased significantly after T(L) compared to the baseline (T(0)), while in group L after T(10). Between two groups, BIS values showed a significant differences only at T(10), BIS of group H was lower than that of group L. Ramsay score showed no significant differences except in T(L); the score of group L was significantly lower than that of group H. Other vital signs and complications showed a minimal differences between two groups. CONCLUSIONS: Higher loading dose (1.0 µg/kg) of dexmedetomidine can lead to faster sedation without any severe complications. The Korean Society of Anesthesiologists 2014-07 2014-07-29 /pmc/articles/PMC4121500/ /pubmed/25097732 http://dx.doi.org/10.4097/kjae.2014.67.1.8 Text en Copyright © the Korean Society of Anesthesiologists, 2014 http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Research Article
Sim, Jae Hwan
Yu, Hyun Jeong
Kim, Sang Tae
The effects of different loading doses of dexmedetomidine on sedation
title The effects of different loading doses of dexmedetomidine on sedation
title_full The effects of different loading doses of dexmedetomidine on sedation
title_fullStr The effects of different loading doses of dexmedetomidine on sedation
title_full_unstemmed The effects of different loading doses of dexmedetomidine on sedation
title_short The effects of different loading doses of dexmedetomidine on sedation
title_sort effects of different loading doses of dexmedetomidine on sedation
topic Clinical Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121500/
https://www.ncbi.nlm.nih.gov/pubmed/25097732
http://dx.doi.org/10.4097/kjae.2014.67.1.8
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