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Potential reproductive health effects and oxidative stress associated with exposure to potassium dichromate (K(2)Cr(2)O(7)) and magnesium sulphate (MgSO(4)) in male mice

Objective: To investigate the potential harmful effects of potassium dichromate and magnesium sulphate causing oxidative stress and reproductive toxicity in adult male mice model. Methods: The experimental work was conducted on sixty male mice (Mus musculus) divided into three groups. Mice in group...

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Autores principales: Rasool, Mahmood, Zaigham, Kalsoom, Malik, Arif, Naseer, Muhammad Imran, Umm-e-Habiba, Manan, Abdul, Qazi, Mahmood Husain, Asif, Muhammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Professional Medical Publicaitons 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121705/
https://www.ncbi.nlm.nih.gov/pubmed/25097524
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author Rasool, Mahmood
Zaigham, Kalsoom
Malik, Arif
Naseer, Muhammad Imran
Umm-e-Habiba,
Manan, Abdul
Qazi, Mahmood Husain
Asif, Muhammad
author_facet Rasool, Mahmood
Zaigham, Kalsoom
Malik, Arif
Naseer, Muhammad Imran
Umm-e-Habiba,
Manan, Abdul
Qazi, Mahmood Husain
Asif, Muhammad
author_sort Rasool, Mahmood
collection PubMed
description Objective: To investigate the potential harmful effects of potassium dichromate and magnesium sulphate causing oxidative stress and reproductive toxicity in adult male mice model. Methods: The experimental work was conducted on sixty male mice (Mus musculus) divided into three groups. Mice in group B and C received potassium dichromate and magnesium sulphate of 5.0 and 500 mg/Kg body weight/ml respectively, for sixty days. The blood sample was analyzed to assess oxidative stress and cellular damage. Results: Results showed high malondialdehyde (MDA) and low levels of antioxidant enzymes [catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx)] in both potassium dichromate and magnesium sulphate administrated groups as compared to control group. Reduced number of sperm count and excessive destruction of testicular follicles, including destruction of spermatids, leydig cells and sertoli cells, were also seen in both groups. Conclusion: We concluded from present study that potassium dichromate and magnesium sulphate causes oxidative stress by generation of reactive oxygen species (ROS) and causing DNA damage in testicular cells leading to adverse reproductive abnormalities.
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spelling pubmed-41217052014-08-05 Potential reproductive health effects and oxidative stress associated with exposure to potassium dichromate (K(2)Cr(2)O(7)) and magnesium sulphate (MgSO(4)) in male mice Rasool, Mahmood Zaigham, Kalsoom Malik, Arif Naseer, Muhammad Imran Umm-e-Habiba, Manan, Abdul Qazi, Mahmood Husain Asif, Muhammad Pak J Med Sci Original Article Objective: To investigate the potential harmful effects of potassium dichromate and magnesium sulphate causing oxidative stress and reproductive toxicity in adult male mice model. Methods: The experimental work was conducted on sixty male mice (Mus musculus) divided into three groups. Mice in group B and C received potassium dichromate and magnesium sulphate of 5.0 and 500 mg/Kg body weight/ml respectively, for sixty days. The blood sample was analyzed to assess oxidative stress and cellular damage. Results: Results showed high malondialdehyde (MDA) and low levels of antioxidant enzymes [catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx)] in both potassium dichromate and magnesium sulphate administrated groups as compared to control group. Reduced number of sperm count and excessive destruction of testicular follicles, including destruction of spermatids, leydig cells and sertoli cells, were also seen in both groups. Conclusion: We concluded from present study that potassium dichromate and magnesium sulphate causes oxidative stress by generation of reactive oxygen species (ROS) and causing DNA damage in testicular cells leading to adverse reproductive abnormalities. Professional Medical Publicaitons 2014 /pmc/articles/PMC4121705/ /pubmed/25097524 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Rasool, Mahmood
Zaigham, Kalsoom
Malik, Arif
Naseer, Muhammad Imran
Umm-e-Habiba,
Manan, Abdul
Qazi, Mahmood Husain
Asif, Muhammad
Potential reproductive health effects and oxidative stress associated with exposure to potassium dichromate (K(2)Cr(2)O(7)) and magnesium sulphate (MgSO(4)) in male mice
title Potential reproductive health effects and oxidative stress associated with exposure to potassium dichromate (K(2)Cr(2)O(7)) and magnesium sulphate (MgSO(4)) in male mice
title_full Potential reproductive health effects and oxidative stress associated with exposure to potassium dichromate (K(2)Cr(2)O(7)) and magnesium sulphate (MgSO(4)) in male mice
title_fullStr Potential reproductive health effects and oxidative stress associated with exposure to potassium dichromate (K(2)Cr(2)O(7)) and magnesium sulphate (MgSO(4)) in male mice
title_full_unstemmed Potential reproductive health effects and oxidative stress associated with exposure to potassium dichromate (K(2)Cr(2)O(7)) and magnesium sulphate (MgSO(4)) in male mice
title_short Potential reproductive health effects and oxidative stress associated with exposure to potassium dichromate (K(2)Cr(2)O(7)) and magnesium sulphate (MgSO(4)) in male mice
title_sort potential reproductive health effects and oxidative stress associated with exposure to potassium dichromate (k(2)cr(2)o(7)) and magnesium sulphate (mgso(4)) in male mice
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121705/
https://www.ncbi.nlm.nih.gov/pubmed/25097524
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