IFITMs Restrict the Replication of Multiple Pathogenic Viruses

The interferon-inducible transmembrane protein (IFITM) family inhibits a growing number of pathogenic viruses, among them influenza A virus, dengue virus, hepatitis C virus, and Ebola virus. This review covers recent developments in our understanding of the IFITM's molecular determinants, poten...

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Detalles Bibliográficos
Autores principales: Perreira, Jill M., Chin, Christopher R., Feeley, Eric M., Brass, Abraham L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121887/
https://www.ncbi.nlm.nih.gov/pubmed/24076421
http://dx.doi.org/10.1016/j.jmb.2013.09.024
Descripción
Sumario:The interferon-inducible transmembrane protein (IFITM) family inhibits a growing number of pathogenic viruses, among them influenza A virus, dengue virus, hepatitis C virus, and Ebola virus. This review covers recent developments in our understanding of the IFITM's molecular determinants, potential mechanisms of action, and impact on pathogenesis.

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