Correlation between 24-h urine protein, spot urine protein/creatinine ratio, and serum uric acid and their association with fetomaternal outcomes in preeclamptic women

BACKGROUND: It is well-known that estimation of 24-h urine protein and spot urine protein/creatinine (P/C) ratio are commonly performed investigations to assess proteinuria in preeclamptic women. Serum uric acid has been shown to correlate well with disease severity in preeclampsia. MATERIALS AND METHODS: A total of 24-h urine protein estimation, spot urine P/C ratio, and serum uric acid measurements were carried out in 75 pregnant preeclamptic women and the correlation between these investigations, as also the association between proteinuria and hyperuricemia with adverse fetomaternal outcomes were studied. RESULTS: Pearson's correlation test showed a positive correlation between 24-h urine protein and spot urine P/C ratio. A statistically significant and direct correlation was also found between serum uric acid and spot urine P/C ratio, while there was no statistically significant difference between proteinuria and hyperuricemia with respect to the various fetal and maternal outcome parameters studied. CONCLUSION: In the present study, we found a moderate correlation between 24-h urine protein and spot urine P/C ratio. There was a moderate correlation between spot urine P/C ratio and uric acid, while there was no statistical significance of the association between proteinuria and uric acid with fetomaternal outcomes in preeclampsia.