Glutathione S-transferase T1 and myeloperoxidase −463 G>A genotypes in lung cancer patients of Kumaun region

BACKGROUND: Null genetic polymorphism of Glutathione S-transferase T1 (GSTT1) and -463 G>A promoter polymorphism of myeloperoxidase (MPO) were studied for association with lung cancer. MATERIALS AND METHODS: In a case- control study 26 lung cancer patients and 33 healthy individuals from hilly Ku...

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Detalles Bibliográficos
Autores principales: Bag, Arundhati, Bag, Niladri, Jeena, Lalit Mohan, Jyala, Narayan Singh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121901/
https://www.ncbi.nlm.nih.gov/pubmed/25097401
http://dx.doi.org/10.4103/0976-9668.136169
Descripción
Sumario:BACKGROUND: Null genetic polymorphism of Glutathione S-transferase T1 (GSTT1) and -463 G>A promoter polymorphism of myeloperoxidase (MPO) were studied for association with lung cancer. MATERIALS AND METHODS: In a case- control study 26 lung cancer patients and 33 healthy individuals from hilly Kumaun region of northern India were investigated. DNA was extracted from peripheral blood. GSTT1 null polymorphism was detected by duplex PCR, and MPO polymorphism was detected by performing PCR-RFLP. RESULTS: An increased but statistically non- significant risk for lung cancer was found for GSTT1 null genotype. No association for MPO -463G>A genotype was evident. CONCLUSION: Further study with large sample size may reveal such association in this population.

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