Glutathione S-transferase T1 and myeloperoxidase −463 G>A genotypes in lung cancer patients of Kumaun region

BACKGROUND: Null genetic polymorphism of Glutathione S-transferase T1 (GSTT1) and -463 G>A promoter polymorphism of myeloperoxidase (MPO) were studied for association with lung cancer. MATERIALS AND METHODS: In a case- control study 26 lung cancer patients and 33 healthy individuals from hilly Ku...

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Autores principales: Bag, Arundhati, Bag, Niladri, Jeena, Lalit Mohan, Jyala, Narayan Singh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121901/
https://www.ncbi.nlm.nih.gov/pubmed/25097401
http://dx.doi.org/10.4103/0976-9668.136169
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author Bag, Arundhati
Bag, Niladri
Jeena, Lalit Mohan
Jyala, Narayan Singh
author_facet Bag, Arundhati
Bag, Niladri
Jeena, Lalit Mohan
Jyala, Narayan Singh
author_sort Bag, Arundhati
collection PubMed
description BACKGROUND: Null genetic polymorphism of Glutathione S-transferase T1 (GSTT1) and -463 G>A promoter polymorphism of myeloperoxidase (MPO) were studied for association with lung cancer. MATERIALS AND METHODS: In a case- control study 26 lung cancer patients and 33 healthy individuals from hilly Kumaun region of northern India were investigated. DNA was extracted from peripheral blood. GSTT1 null polymorphism was detected by duplex PCR, and MPO polymorphism was detected by performing PCR-RFLP. RESULTS: An increased but statistically non- significant risk for lung cancer was found for GSTT1 null genotype. No association for MPO -463G>A genotype was evident. CONCLUSION: Further study with large sample size may reveal such association in this population.
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spelling pubmed-41219012014-08-05 Glutathione S-transferase T1 and myeloperoxidase −463 G>A genotypes in lung cancer patients of Kumaun region Bag, Arundhati Bag, Niladri Jeena, Lalit Mohan Jyala, Narayan Singh J Nat Sci Biol Med Original Article BACKGROUND: Null genetic polymorphism of Glutathione S-transferase T1 (GSTT1) and -463 G>A promoter polymorphism of myeloperoxidase (MPO) were studied for association with lung cancer. MATERIALS AND METHODS: In a case- control study 26 lung cancer patients and 33 healthy individuals from hilly Kumaun region of northern India were investigated. DNA was extracted from peripheral blood. GSTT1 null polymorphism was detected by duplex PCR, and MPO polymorphism was detected by performing PCR-RFLP. RESULTS: An increased but statistically non- significant risk for lung cancer was found for GSTT1 null genotype. No association for MPO -463G>A genotype was evident. CONCLUSION: Further study with large sample size may reveal such association in this population. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4121901/ /pubmed/25097401 http://dx.doi.org/10.4103/0976-9668.136169 Text en Copyright: © Journal of Natural Science, Biology and Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Bag, Arundhati
Bag, Niladri
Jeena, Lalit Mohan
Jyala, Narayan Singh
Glutathione S-transferase T1 and myeloperoxidase −463 G>A genotypes in lung cancer patients of Kumaun region
title Glutathione S-transferase T1 and myeloperoxidase −463 G>A genotypes in lung cancer patients of Kumaun region
title_full Glutathione S-transferase T1 and myeloperoxidase −463 G>A genotypes in lung cancer patients of Kumaun region
title_fullStr Glutathione S-transferase T1 and myeloperoxidase −463 G>A genotypes in lung cancer patients of Kumaun region
title_full_unstemmed Glutathione S-transferase T1 and myeloperoxidase −463 G>A genotypes in lung cancer patients of Kumaun region
title_short Glutathione S-transferase T1 and myeloperoxidase −463 G>A genotypes in lung cancer patients of Kumaun region
title_sort glutathione s-transferase t1 and myeloperoxidase −463 g>a genotypes in lung cancer patients of kumaun region
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121901/
https://www.ncbi.nlm.nih.gov/pubmed/25097401
http://dx.doi.org/10.4103/0976-9668.136169
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