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Diagnostic and prognostic significance of different mucin expression, preoperative CEA, and CA-125 in colorectal carcinoma: A clinicopathological study

BACKGROUND: Colorectal carcinoma (CRC) is the fourth most commonly diagnosed malignant disease worldwide, with over 1 million new cases and approximately 5,00,000 deaths each year. AIMS AND OBJECTIVES: This prospective observational study was done to study the clinicopathological characteristics of...

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Autores principales: Jain, Parul, Mondal, Santosh Kumar, Sinha, Swapan Kumar, Mukhopadhyay, Mrityunjoy, Chakraborty, Indranil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121924/
https://www.ncbi.nlm.nih.gov/pubmed/25097424
http://dx.doi.org/10.4103/0976-9668.136207
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author Jain, Parul
Mondal, Santosh Kumar
Sinha, Swapan Kumar
Mukhopadhyay, Mrityunjoy
Chakraborty, Indranil
author_facet Jain, Parul
Mondal, Santosh Kumar
Sinha, Swapan Kumar
Mukhopadhyay, Mrityunjoy
Chakraborty, Indranil
author_sort Jain, Parul
collection PubMed
description BACKGROUND: Colorectal carcinoma (CRC) is the fourth most commonly diagnosed malignant disease worldwide, with over 1 million new cases and approximately 5,00,000 deaths each year. AIMS AND OBJECTIVES: This prospective observational study was done to study the clinicopathological characteristics of CRC including mucin stains and correlate the preoperative serum carcinoembryonic antigen (CEA) and cancer antigen (CA)-125 levels with the prognosis. MATERIALS AND METHODS: A total of 90 CRCs were included from December 2010 to June 2013. Detailed history and relevant clinical/radiological findings were noted in all clinically and/or radiologically suspected cases of CRC. Preoperative blood samples were collected for serum CEA and CA-125 level estimation. The mucin expression was evaluated with special stains. RESULTS: The combined Alcian blue-periodic acid Schiff (PAS) staining was positive for both stains in 68.88% cases indicating that both neutral and acidic mucins are increased in CRC. High preoperative serum CEA levels were seen in 82.22% cases, whereas preoperative serum CA-125 levels showed an increase in 20% cases. Higher levels of these tumor markers corresponded with higher TNM stage. CONCLUSIONS: Mucin evaluation in CRCs remains one of the valuable methods as mucinous variants correlate with worse prognosis. Preoperative serum CEA level assessment is an indispensible adjunct to the diagnosis and prognosis of CRC. However, preoperative serum CA-125 level measurement is not an efficient tool for prognostication in CRC and should not be recommended for routine use.
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spelling pubmed-41219242014-08-05 Diagnostic and prognostic significance of different mucin expression, preoperative CEA, and CA-125 in colorectal carcinoma: A clinicopathological study Jain, Parul Mondal, Santosh Kumar Sinha, Swapan Kumar Mukhopadhyay, Mrityunjoy Chakraborty, Indranil J Nat Sci Biol Med Original Article BACKGROUND: Colorectal carcinoma (CRC) is the fourth most commonly diagnosed malignant disease worldwide, with over 1 million new cases and approximately 5,00,000 deaths each year. AIMS AND OBJECTIVES: This prospective observational study was done to study the clinicopathological characteristics of CRC including mucin stains and correlate the preoperative serum carcinoembryonic antigen (CEA) and cancer antigen (CA)-125 levels with the prognosis. MATERIALS AND METHODS: A total of 90 CRCs were included from December 2010 to June 2013. Detailed history and relevant clinical/radiological findings were noted in all clinically and/or radiologically suspected cases of CRC. Preoperative blood samples were collected for serum CEA and CA-125 level estimation. The mucin expression was evaluated with special stains. RESULTS: The combined Alcian blue-periodic acid Schiff (PAS) staining was positive for both stains in 68.88% cases indicating that both neutral and acidic mucins are increased in CRC. High preoperative serum CEA levels were seen in 82.22% cases, whereas preoperative serum CA-125 levels showed an increase in 20% cases. Higher levels of these tumor markers corresponded with higher TNM stage. CONCLUSIONS: Mucin evaluation in CRCs remains one of the valuable methods as mucinous variants correlate with worse prognosis. Preoperative serum CEA level assessment is an indispensible adjunct to the diagnosis and prognosis of CRC. However, preoperative serum CA-125 level measurement is not an efficient tool for prognostication in CRC and should not be recommended for routine use. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4121924/ /pubmed/25097424 http://dx.doi.org/10.4103/0976-9668.136207 Text en Copyright: © Journal of Natural Science, Biology and Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Jain, Parul
Mondal, Santosh Kumar
Sinha, Swapan Kumar
Mukhopadhyay, Mrityunjoy
Chakraborty, Indranil
Diagnostic and prognostic significance of different mucin expression, preoperative CEA, and CA-125 in colorectal carcinoma: A clinicopathological study
title Diagnostic and prognostic significance of different mucin expression, preoperative CEA, and CA-125 in colorectal carcinoma: A clinicopathological study
title_full Diagnostic and prognostic significance of different mucin expression, preoperative CEA, and CA-125 in colorectal carcinoma: A clinicopathological study
title_fullStr Diagnostic and prognostic significance of different mucin expression, preoperative CEA, and CA-125 in colorectal carcinoma: A clinicopathological study
title_full_unstemmed Diagnostic and prognostic significance of different mucin expression, preoperative CEA, and CA-125 in colorectal carcinoma: A clinicopathological study
title_short Diagnostic and prognostic significance of different mucin expression, preoperative CEA, and CA-125 in colorectal carcinoma: A clinicopathological study
title_sort diagnostic and prognostic significance of different mucin expression, preoperative cea, and ca-125 in colorectal carcinoma: a clinicopathological study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121924/
https://www.ncbi.nlm.nih.gov/pubmed/25097424
http://dx.doi.org/10.4103/0976-9668.136207
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