Cargando…
Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease
Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder associated with allergic hypersensitivity to food. We interrogated >1.5 million genetic variants in European EoE cases and subsequently in a multi-site cohort with local and out-of-study control subjects. In addition to replication...
Autores principales: | Kottyan, Leah C., Davis, Benjamin P., Sherrill, Joseph D., Liu, Kan, Rochman, Mark, Kaufman, Kenneth, Weirauch, Matthew T., Vaughn, Samuel, Lazaro, Sara, Rupert, Andrew M., Kohram, Mojtaba, Stucke, Emily M., Kemme, Katherine A., Magnusen, Albert, He, Hua, Dexheimer, Phillip, Chehade, Mirna, Wood, Robert A., Pesek, Robbie D., Vickery, Brian P., Fleischer, David M., Lindbad, Robert, Sampson, Hugh A., Mukkada, Vince, Putnam, Phil E., Abonia, J. Pablo, Martin, Lisa J., Harley, John B., Rothenberg, Marc E. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121957/ https://www.ncbi.nlm.nih.gov/pubmed/25017104 http://dx.doi.org/10.1038/ng.3033 |
Ejemplares similares
-
Genetic variants at the 16p13 locus confer risk for eosinophilic esophagitis
por: Kottyan, Leah C., et al.
Publicado: (2018) -
Analysis and expansion of the eosinophilic esophagitis transcriptome by RNA sequencing
por: Sherrill, Joseph D., et al.
Publicado: (2014) -
Cadherin 26 is an alpha integrin-binding epithelial receptor regulated during allergic inflammation
por: Caldwell, Julie M., et al.
Publicado: (2017) -
Desmoglein-1 regulates esophageal epithelial barrier function and immune responses in eosinophilic esophagitis
por: Sherrill, J D, et al.
Publicado: (2013) -
Neurotrophic tyrosine kinase receptor 1 is a direct transcriptional and epigenetic target of IL-13 involved in allergic inflammation
por: Rochman, M., et al.
Publicado: (2014)