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A unified cell biological perspective on axon–myelin injury
Demyelination and axon loss are pathological hallmarks of the neuroinflammatory disorder multiple sclerosis (MS). Although we have an increasingly detailed understanding of how immune cells can damage axons and myelin individually, we lack a unified view of how the axon–myelin unit as a whole is aff...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121977/ https://www.ncbi.nlm.nih.gov/pubmed/25092654 http://dx.doi.org/10.1083/jcb.201404154 |
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author | Simons, Mikael Misgeld, Thomas Kerschensteiner, Martin |
author_facet | Simons, Mikael Misgeld, Thomas Kerschensteiner, Martin |
author_sort | Simons, Mikael |
collection | PubMed |
description | Demyelination and axon loss are pathological hallmarks of the neuroinflammatory disorder multiple sclerosis (MS). Although we have an increasingly detailed understanding of how immune cells can damage axons and myelin individually, we lack a unified view of how the axon–myelin unit as a whole is affected by immune-mediated attack. In this review, we propose that as a result of the tight cell biological interconnection of axons and myelin, damage to either can spread, which might convert a local inflammatory disease process early in MS into the global progressive disorder seen during later stages. This mode of spreading could also apply to other neurological disorders. |
format | Online Article Text |
id | pubmed-4121977 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-41219772015-02-04 A unified cell biological perspective on axon–myelin injury Simons, Mikael Misgeld, Thomas Kerschensteiner, Martin J Cell Biol Reviews Demyelination and axon loss are pathological hallmarks of the neuroinflammatory disorder multiple sclerosis (MS). Although we have an increasingly detailed understanding of how immune cells can damage axons and myelin individually, we lack a unified view of how the axon–myelin unit as a whole is affected by immune-mediated attack. In this review, we propose that as a result of the tight cell biological interconnection of axons and myelin, damage to either can spread, which might convert a local inflammatory disease process early in MS into the global progressive disorder seen during later stages. This mode of spreading could also apply to other neurological disorders. The Rockefeller University Press 2014-08-04 /pmc/articles/PMC4121977/ /pubmed/25092654 http://dx.doi.org/10.1083/jcb.201404154 Text en © 2014 Simons et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). |
spellingShingle | Reviews Simons, Mikael Misgeld, Thomas Kerschensteiner, Martin A unified cell biological perspective on axon–myelin injury |
title | A unified cell biological perspective on axon–myelin injury |
title_full | A unified cell biological perspective on axon–myelin injury |
title_fullStr | A unified cell biological perspective on axon–myelin injury |
title_full_unstemmed | A unified cell biological perspective on axon–myelin injury |
title_short | A unified cell biological perspective on axon–myelin injury |
title_sort | unified cell biological perspective on axon–myelin injury |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121977/ https://www.ncbi.nlm.nih.gov/pubmed/25092654 http://dx.doi.org/10.1083/jcb.201404154 |
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