Cell Death and Inflammatory Bowel Diseases: Apoptosis, Necrosis, and Autophagy in the Intestinal Epithelium

Cell death mechanisms have been associated with the development of inflammatory bowel diseases in humans and mice. Recent studies suggested that a complex crosstalk between autophagy/apoptosis, microbe sensing, and enhanced endoplasmic reticulum stress in the epithelium could play a critical role in...

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Detalles Bibliográficos
Autores principales: Nunes, Tiago, Bernardazzi, Claudio, de Souza, Heitor S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121991/
https://www.ncbi.nlm.nih.gov/pubmed/25126549
http://dx.doi.org/10.1155/2014/218493
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author Nunes, Tiago
Bernardazzi, Claudio
de Souza, Heitor S.
author_facet Nunes, Tiago
Bernardazzi, Claudio
de Souza, Heitor S.
author_sort Nunes, Tiago
collection PubMed
description Cell death mechanisms have been associated with the development of inflammatory bowel diseases in humans and mice. Recent studies suggested that a complex crosstalk between autophagy/apoptosis, microbe sensing, and enhanced endoplasmic reticulum stress in the epithelium could play a critical role in these diseases. In addition, necroptosis, a relatively novel programmed necrosis-like pathway associated with TNF receptor activation, seems to be also present in the pathogenesis of Crohn's disease and in specific animal models for intestinal inflammation. This review attempts to cover new data related to cell death mechanisms and inflammatory bowel diseases.
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spelling pubmed-41219912014-08-14 Cell Death and Inflammatory Bowel Diseases: Apoptosis, Necrosis, and Autophagy in the Intestinal Epithelium Nunes, Tiago Bernardazzi, Claudio de Souza, Heitor S. Biomed Res Int Review Article Cell death mechanisms have been associated with the development of inflammatory bowel diseases in humans and mice. Recent studies suggested that a complex crosstalk between autophagy/apoptosis, microbe sensing, and enhanced endoplasmic reticulum stress in the epithelium could play a critical role in these diseases. In addition, necroptosis, a relatively novel programmed necrosis-like pathway associated with TNF receptor activation, seems to be also present in the pathogenesis of Crohn's disease and in specific animal models for intestinal inflammation. This review attempts to cover new data related to cell death mechanisms and inflammatory bowel diseases. Hindawi Publishing Corporation 2014 2014-07-14 /pmc/articles/PMC4121991/ /pubmed/25126549 http://dx.doi.org/10.1155/2014/218493 Text en Copyright © 2014 Tiago Nunes et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Nunes, Tiago
Bernardazzi, Claudio
de Souza, Heitor S.
Cell Death and Inflammatory Bowel Diseases: Apoptosis, Necrosis, and Autophagy in the Intestinal Epithelium
title Cell Death and Inflammatory Bowel Diseases: Apoptosis, Necrosis, and Autophagy in the Intestinal Epithelium
title_full Cell Death and Inflammatory Bowel Diseases: Apoptosis, Necrosis, and Autophagy in the Intestinal Epithelium
title_fullStr Cell Death and Inflammatory Bowel Diseases: Apoptosis, Necrosis, and Autophagy in the Intestinal Epithelium
title_full_unstemmed Cell Death and Inflammatory Bowel Diseases: Apoptosis, Necrosis, and Autophagy in the Intestinal Epithelium
title_short Cell Death and Inflammatory Bowel Diseases: Apoptosis, Necrosis, and Autophagy in the Intestinal Epithelium
title_sort cell death and inflammatory bowel diseases: apoptosis, necrosis, and autophagy in the intestinal epithelium
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121991/
https://www.ncbi.nlm.nih.gov/pubmed/25126549
http://dx.doi.org/10.1155/2014/218493
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