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Changes in complex spike activity during classical conditioning

The cerebellar cortex is necessary for adaptively timed conditioned responses (CRs) in eyeblink conditioning. During conditioning, Purkinje cells acquire pause responses or “Purkinje cell CRs” to the conditioned stimuli (CS), resulting in disinhibition of the cerebellar nuclei (CN), allowing them to...

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Autores principales: Rasmussen, Anders, Jirenhed, Dan-Anders, Wetmore, Daniel Z., Hesslow, Germund
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122208/
https://www.ncbi.nlm.nih.gov/pubmed/25140129
http://dx.doi.org/10.3389/fncir.2014.00090
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author Rasmussen, Anders
Jirenhed, Dan-Anders
Wetmore, Daniel Z.
Hesslow, Germund
author_facet Rasmussen, Anders
Jirenhed, Dan-Anders
Wetmore, Daniel Z.
Hesslow, Germund
author_sort Rasmussen, Anders
collection PubMed
description The cerebellar cortex is necessary for adaptively timed conditioned responses (CRs) in eyeblink conditioning. During conditioning, Purkinje cells acquire pause responses or “Purkinje cell CRs” to the conditioned stimuli (CS), resulting in disinhibition of the cerebellar nuclei (CN), allowing them to activate motor nuclei that control eyeblinks. This disinhibition also causes inhibition of the inferior olive (IO), via the nucleo-olivary pathway (N-O). Activation of the IO, which relays the unconditional stimulus (US) to the cortex, elicits characteristic complex spikes in Purkinje cells. Although Purkinje cell activity, as well as stimulation of the CN, is known to influence IO activity, much remains to be learned about the way that learned changes in simple spike firing affects the IO. In the present study, we analyzed changes in simple and complex spike firing, in extracellular Purkinje cell records, from the C3 zone, in decerebrate ferrets undergoing training in a conditioning paradigm. In agreement with the N-O feedback hypothesis, acquisition resulted in a gradual decrease in complex spike activity during the conditioned stimulus, with a delay that is consistent with the long N-O latency. Also supporting the feedback hypothesis, training with a short interstimulus interval (ISI), which does not lead to acquisition of a Purkinje cell CR, did not cause a suppression of complex spike activity. In contrast, observations that extinction did not lead to a recovery in complex spike activity and the irregular patterns of simple and complex spike activity after the conditioned stimulus are less conclusive.
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spelling pubmed-41222082014-08-19 Changes in complex spike activity during classical conditioning Rasmussen, Anders Jirenhed, Dan-Anders Wetmore, Daniel Z. Hesslow, Germund Front Neural Circuits Neuroscience The cerebellar cortex is necessary for adaptively timed conditioned responses (CRs) in eyeblink conditioning. During conditioning, Purkinje cells acquire pause responses or “Purkinje cell CRs” to the conditioned stimuli (CS), resulting in disinhibition of the cerebellar nuclei (CN), allowing them to activate motor nuclei that control eyeblinks. This disinhibition also causes inhibition of the inferior olive (IO), via the nucleo-olivary pathway (N-O). Activation of the IO, which relays the unconditional stimulus (US) to the cortex, elicits characteristic complex spikes in Purkinje cells. Although Purkinje cell activity, as well as stimulation of the CN, is known to influence IO activity, much remains to be learned about the way that learned changes in simple spike firing affects the IO. In the present study, we analyzed changes in simple and complex spike firing, in extracellular Purkinje cell records, from the C3 zone, in decerebrate ferrets undergoing training in a conditioning paradigm. In agreement with the N-O feedback hypothesis, acquisition resulted in a gradual decrease in complex spike activity during the conditioned stimulus, with a delay that is consistent with the long N-O latency. Also supporting the feedback hypothesis, training with a short interstimulus interval (ISI), which does not lead to acquisition of a Purkinje cell CR, did not cause a suppression of complex spike activity. In contrast, observations that extinction did not lead to a recovery in complex spike activity and the irregular patterns of simple and complex spike activity after the conditioned stimulus are less conclusive. Frontiers Media S.A. 2014-08-05 /pmc/articles/PMC4122208/ /pubmed/25140129 http://dx.doi.org/10.3389/fncir.2014.00090 Text en Copyright © 2014 Rasmussen, Jirenhed, Wetmore and Hesslow. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Rasmussen, Anders
Jirenhed, Dan-Anders
Wetmore, Daniel Z.
Hesslow, Germund
Changes in complex spike activity during classical conditioning
title Changes in complex spike activity during classical conditioning
title_full Changes in complex spike activity during classical conditioning
title_fullStr Changes in complex spike activity during classical conditioning
title_full_unstemmed Changes in complex spike activity during classical conditioning
title_short Changes in complex spike activity during classical conditioning
title_sort changes in complex spike activity during classical conditioning
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122208/
https://www.ncbi.nlm.nih.gov/pubmed/25140129
http://dx.doi.org/10.3389/fncir.2014.00090
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