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Cues, context, and long-term memory: the role of the retrosplenial cortex in spatial cognition

Spatial navigation requires memory representations of landmarks and other navigation cues. The retrosplenial cortex (RSC) is anatomically positioned between limbic areas important for memory formation, such as the hippocampus (HPC) and the anterior thalamus, and cortical regions along the dorsal str...

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Autores principales: Miller, Adam M. P., Vedder, Lindsey C., Law, L. Matthew, Smith, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122222/
https://www.ncbi.nlm.nih.gov/pubmed/25140141
http://dx.doi.org/10.3389/fnhum.2014.00586
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author Miller, Adam M. P.
Vedder, Lindsey C.
Law, L. Matthew
Smith, David M.
author_facet Miller, Adam M. P.
Vedder, Lindsey C.
Law, L. Matthew
Smith, David M.
author_sort Miller, Adam M. P.
collection PubMed
description Spatial navigation requires memory representations of landmarks and other navigation cues. The retrosplenial cortex (RSC) is anatomically positioned between limbic areas important for memory formation, such as the hippocampus (HPC) and the anterior thalamus, and cortical regions along the dorsal stream known to contribute importantly to long-term spatial representation, such as the posterior parietal cortex. Damage to the RSC severely impairs allocentric representations of the environment, including the ability to derive navigational information from landmarks. The specific deficits seen in tests of human and rodent navigation suggest that the RSC supports allocentric representation by processing the stable features of the environment and the spatial relationships among them. In addition to spatial cognition, the RSC plays a key role in contextual and episodic memory. The RSC also contributes importantly to the acquisition and consolidation of long-term spatial and contextual memory through its interactions with the HPC. Within this framework, the RSC plays a dual role as part of the feedforward network providing sensory and mnemonic input to the HPC and as a target of the hippocampal-dependent systems consolidation of long-term memory.
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spelling pubmed-41222222014-08-19 Cues, context, and long-term memory: the role of the retrosplenial cortex in spatial cognition Miller, Adam M. P. Vedder, Lindsey C. Law, L. Matthew Smith, David M. Front Hum Neurosci Neuroscience Spatial navigation requires memory representations of landmarks and other navigation cues. The retrosplenial cortex (RSC) is anatomically positioned between limbic areas important for memory formation, such as the hippocampus (HPC) and the anterior thalamus, and cortical regions along the dorsal stream known to contribute importantly to long-term spatial representation, such as the posterior parietal cortex. Damage to the RSC severely impairs allocentric representations of the environment, including the ability to derive navigational information from landmarks. The specific deficits seen in tests of human and rodent navigation suggest that the RSC supports allocentric representation by processing the stable features of the environment and the spatial relationships among them. In addition to spatial cognition, the RSC plays a key role in contextual and episodic memory. The RSC also contributes importantly to the acquisition and consolidation of long-term spatial and contextual memory through its interactions with the HPC. Within this framework, the RSC plays a dual role as part of the feedforward network providing sensory and mnemonic input to the HPC and as a target of the hippocampal-dependent systems consolidation of long-term memory. Frontiers Media S.A. 2014-08-05 /pmc/articles/PMC4122222/ /pubmed/25140141 http://dx.doi.org/10.3389/fnhum.2014.00586 Text en Copyright © 2014 Miller, Vedder, Law and Smith. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Miller, Adam M. P.
Vedder, Lindsey C.
Law, L. Matthew
Smith, David M.
Cues, context, and long-term memory: the role of the retrosplenial cortex in spatial cognition
title Cues, context, and long-term memory: the role of the retrosplenial cortex in spatial cognition
title_full Cues, context, and long-term memory: the role of the retrosplenial cortex in spatial cognition
title_fullStr Cues, context, and long-term memory: the role of the retrosplenial cortex in spatial cognition
title_full_unstemmed Cues, context, and long-term memory: the role of the retrosplenial cortex in spatial cognition
title_short Cues, context, and long-term memory: the role of the retrosplenial cortex in spatial cognition
title_sort cues, context, and long-term memory: the role of the retrosplenial cortex in spatial cognition
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122222/
https://www.ncbi.nlm.nih.gov/pubmed/25140141
http://dx.doi.org/10.3389/fnhum.2014.00586
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