Systematic Repurposing Screening in Xenograft Models Identifies Approved Drugs with Novel Anti-Cancer Activity

Approved drugs target approximately 400 different mechanisms of action, of which as few as 60 are currently used as anti-cancer therapies. Given that on average it takes 10–15 years for a new cancer therapeutic to be approved, and the recent success of drug repurposing for agents such as thalidomide...

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Detalles Bibliográficos
Autores principales: Roix, Jeffrey J., Harrison, S. D., Rainbolt, Elizabeth A., Meshaw, Kathryn R., McMurry, Avery S., Cheung, Peter, Saha, Saurabh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122340/
https://www.ncbi.nlm.nih.gov/pubmed/25093583
http://dx.doi.org/10.1371/journal.pone.0101708

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122340/
https://www.ncbi.nlm.nih.gov/pubmed/25093583
http://dx.doi.org/10.1371/journal.pone.0101708

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