Inhibition of CaMKII Does Not Attenuate Cardiac Hypertrophy in Mice with Dysfunctional Ryanodine Receptor

In cardiac muscle, the release of calcium ions from the sarcoplasmic reticulum through ryanodine receptor ion channels (RyR2s) leads to muscle contraction. RyR2 is negatively regulated by calmodulin (CaM) and by phosphorylation of Ca(2+)/CaM-dependent protein kinase II (CaMKII). Substitution of thre...

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Detalles Bibliográficos
Autores principales: Chakraborty, Asima, Pasek, Daniel A., Huang, Tai-Qin, Gomez, Angela C., Yamaguchi, Naohiro, Anderson, Mark E., Meissner, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122402/
https://www.ncbi.nlm.nih.gov/pubmed/25093823
http://dx.doi.org/10.1371/journal.pone.0104338

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