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A New 2α,5α,10β,14β-tetraacetoxy-4(20),11-taxadiene (SIA) Derivative Overcomes Paclitaxel Resistance by Inhibiting MAPK Signaling and Increasing Paclitaxel Accumulation in Breast Cancer Cells

Tumor resistance due to multiple mechanisms seriously hinders the efficacy of chemotherapy drugs such as paclitaxel. The most widely studied P-glycoprotein inhibitors still have limited ability to reverse resistance in the clinic. In this study, NPB304, a novel Sinenxan A (SIA) derivative, was found...

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Detalles Bibliográficos
Autores principales:	Mei, Mei, Xie, Dan, Zhang, Yi, Jin, Jing, You, Feng, Li, Yan, Dai, Jungui, Chen, Xiaoguang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122450/ https://www.ncbi.nlm.nih.gov/pubmed/25093335 http://dx.doi.org/10.1371/journal.pone.0104317

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