Chemo-Enzymatic Synthesis of Ester-Linked 2-Phenylindole-3-Carboxaldehyde-Monosaccharide Conjugate as Potential Prodrug

Chemo-enzymatic synthesis of ester-linked 2-phenylindole-3-carboxaldehyde-glucose conjugate (2-phenylindole-3-carboxyl-10″-O-β-D-glucosyl ester) was achieved by using plant cell cultures as biocatalysts. The anticancer agent, 2-phenylindole-3-carboxaldehyde, induced apoptosis in cells, whereas 2-phe...

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Detalles Bibliográficos
Autores principales: Shimoda, Kei, Hamada, Manabu, Yokoi, Hiroshi, Hamada, Hiroki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122544/
https://www.ncbi.nlm.nih.gov/pubmed/25114553
http://dx.doi.org/10.4137/BCI.S9961
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author Shimoda, Kei
Hamada, Manabu
Yokoi, Hiroshi
Hamada, Hiroki
author_facet Shimoda, Kei
Hamada, Manabu
Yokoi, Hiroshi
Hamada, Hiroki
author_sort Shimoda, Kei
collection PubMed
description Chemo-enzymatic synthesis of ester-linked 2-phenylindole-3-carboxaldehyde-glucose conjugate (2-phenylindole-3-carboxyl-10″-O-β-D-glucosyl ester) was achieved by using plant cell cultures as biocatalysts. The anticancer agent, 2-phenylindole-3-carboxaldehyde, induced apoptosis in cells, whereas 2-phenylindole-3-carboxyl-10″-O-β-D-glucosyl ester showed no cytotoxicity and induced no apoptosis.
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spelling pubmed-41225442014-08-11 Chemo-Enzymatic Synthesis of Ester-Linked 2-Phenylindole-3-Carboxaldehyde-Monosaccharide Conjugate as Potential Prodrug Shimoda, Kei Hamada, Manabu Yokoi, Hiroshi Hamada, Hiroki Biochem Insights Original Research Chemo-enzymatic synthesis of ester-linked 2-phenylindole-3-carboxaldehyde-glucose conjugate (2-phenylindole-3-carboxyl-10″-O-β-D-glucosyl ester) was achieved by using plant cell cultures as biocatalysts. The anticancer agent, 2-phenylindole-3-carboxaldehyde, induced apoptosis in cells, whereas 2-phenylindole-3-carboxyl-10″-O-β-D-glucosyl ester showed no cytotoxicity and induced no apoptosis. Libertas Academica 2012-08-27 /pmc/articles/PMC4122544/ /pubmed/25114553 http://dx.doi.org/10.4137/BCI.S9961 Text en © 2012 the author(s), publisher and licensee Libertas Academica Ltd. This is an open access article. Unrestricted non-commercial use is permitted provided the original work is properly cited.
spellingShingle Original Research
Shimoda, Kei
Hamada, Manabu
Yokoi, Hiroshi
Hamada, Hiroki
Chemo-Enzymatic Synthesis of Ester-Linked 2-Phenylindole-3-Carboxaldehyde-Monosaccharide Conjugate as Potential Prodrug
title Chemo-Enzymatic Synthesis of Ester-Linked 2-Phenylindole-3-Carboxaldehyde-Monosaccharide Conjugate as Potential Prodrug
title_full Chemo-Enzymatic Synthesis of Ester-Linked 2-Phenylindole-3-Carboxaldehyde-Monosaccharide Conjugate as Potential Prodrug
title_fullStr Chemo-Enzymatic Synthesis of Ester-Linked 2-Phenylindole-3-Carboxaldehyde-Monosaccharide Conjugate as Potential Prodrug
title_full_unstemmed Chemo-Enzymatic Synthesis of Ester-Linked 2-Phenylindole-3-Carboxaldehyde-Monosaccharide Conjugate as Potential Prodrug
title_short Chemo-Enzymatic Synthesis of Ester-Linked 2-Phenylindole-3-Carboxaldehyde-Monosaccharide Conjugate as Potential Prodrug
title_sort chemo-enzymatic synthesis of ester-linked 2-phenylindole-3-carboxaldehyde-monosaccharide conjugate as potential prodrug
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122544/
https://www.ncbi.nlm.nih.gov/pubmed/25114553
http://dx.doi.org/10.4137/BCI.S9961
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AT yokoihiroshi chemoenzymaticsynthesisofesterlinked2phenylindole3carboxaldehydemonosaccharideconjugateaspotentialprodrug
AT hamadahiroki chemoenzymaticsynthesisofesterlinked2phenylindole3carboxaldehydemonosaccharideconjugateaspotentialprodrug

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