In Vivo Monitoring of Natural Killer Cell Trafficking During Tumor Immunotherapy

Natural killer (NK) cells are a crucial part of the innate immune system and play critical roles in host anti-viral, anti-microbial, and antitumor responses. The elucidation of NK cell biology and their therapeutic use are actively being pursued with 200 clinical trials currently underway. In this r...

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Detalles Bibliográficos
Autores principales: Sta Maria, Naomi S, Barnes, Samuel R, Jacobs, Russell E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122546/
https://www.ncbi.nlm.nih.gov/pubmed/25114550
http://dx.doi.org/10.4137/MRI.S13145
Descripción
Sumario:Natural killer (NK) cells are a crucial part of the innate immune system and play critical roles in host anti-viral, anti-microbial, and antitumor responses. The elucidation of NK cell biology and their therapeutic use are actively being pursued with 200 clinical trials currently underway. In this review, we outline the role of NK cells in cancer immunotherapies and summarize current noninvasive imaging technologies used to track NK cells in vivo to investigate mechanisms of action, develop new therapies, and evaluate efficacy of adoptive transfer.

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