In Vivo Monitoring of Natural Killer Cell Trafficking During Tumor Immunotherapy

Natural killer (NK) cells are a crucial part of the innate immune system and play critical roles in host anti-viral, anti-microbial, and antitumor responses. The elucidation of NK cell biology and their therapeutic use are actively being pursued with 200 clinical trials currently underway. In this r...

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Detalles Bibliográficos
Autores principales: Sta Maria, Naomi S, Barnes, Samuel R, Jacobs, Russell E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122546/
https://www.ncbi.nlm.nih.gov/pubmed/25114550
http://dx.doi.org/10.4137/MRI.S13145
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author Sta Maria, Naomi S
Barnes, Samuel R
Jacobs, Russell E
author_facet Sta Maria, Naomi S
Barnes, Samuel R
Jacobs, Russell E
author_sort Sta Maria, Naomi S
collection PubMed
description Natural killer (NK) cells are a crucial part of the innate immune system and play critical roles in host anti-viral, anti-microbial, and antitumor responses. The elucidation of NK cell biology and their therapeutic use are actively being pursued with 200 clinical trials currently underway. In this review, we outline the role of NK cells in cancer immunotherapies and summarize current noninvasive imaging technologies used to track NK cells in vivo to investigate mechanisms of action, develop new therapies, and evaluate efficacy of adoptive transfer.
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spelling pubmed-41225462014-08-11 In Vivo Monitoring of Natural Killer Cell Trafficking During Tumor Immunotherapy Sta Maria, Naomi S Barnes, Samuel R Jacobs, Russell E Magn Reson Insights Review Natural killer (NK) cells are a crucial part of the innate immune system and play critical roles in host anti-viral, anti-microbial, and antitumor responses. The elucidation of NK cell biology and their therapeutic use are actively being pursued with 200 clinical trials currently underway. In this review, we outline the role of NK cells in cancer immunotherapies and summarize current noninvasive imaging technologies used to track NK cells in vivo to investigate mechanisms of action, develop new therapies, and evaluate efficacy of adoptive transfer. Libertas Academica 2014-06-05 /pmc/articles/PMC4122546/ /pubmed/25114550 http://dx.doi.org/10.4137/MRI.S13145 Text en © 2014 the author(s), publisher and licensee Libertas Academica Ltd. This is an open access article published under the Creative Commons CC-BY-NC 3.0 License.
spellingShingle Review
Sta Maria, Naomi S
Barnes, Samuel R
Jacobs, Russell E
In Vivo Monitoring of Natural Killer Cell Trafficking During Tumor Immunotherapy
title In Vivo Monitoring of Natural Killer Cell Trafficking During Tumor Immunotherapy
title_full In Vivo Monitoring of Natural Killer Cell Trafficking During Tumor Immunotherapy
title_fullStr In Vivo Monitoring of Natural Killer Cell Trafficking During Tumor Immunotherapy
title_full_unstemmed In Vivo Monitoring of Natural Killer Cell Trafficking During Tumor Immunotherapy
title_short In Vivo Monitoring of Natural Killer Cell Trafficking During Tumor Immunotherapy
title_sort in vivo monitoring of natural killer cell trafficking during tumor immunotherapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122546/
https://www.ncbi.nlm.nih.gov/pubmed/25114550
http://dx.doi.org/10.4137/MRI.S13145
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