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Hemorrhage in mouse tumors induced by dodecaborate cluster lipids intended for boron neutron capture therapy
The potential of boron-containing lipids with three different structures, which were intended for use in boron neutron capture therapy, was investigated. All three types of boron lipids contained the anionic dodecaborate cluster as the headgroup. Their effects on two different tumor models in mice f...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122578/ https://www.ncbi.nlm.nih.gov/pubmed/25114527 http://dx.doi.org/10.2147/IJN.S65166 |
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author | Schaffran, Tanja Jiang, Nan Bergmann, Markus Küstermann, Ekkehard Süss, Regine Schubert, Rolf Wagner, Franz M Awad, Doaa Gabel, Detlef |
author_facet | Schaffran, Tanja Jiang, Nan Bergmann, Markus Küstermann, Ekkehard Süss, Regine Schubert, Rolf Wagner, Franz M Awad, Doaa Gabel, Detlef |
author_sort | Schaffran, Tanja |
collection | PubMed |
description | The potential of boron-containing lipids with three different structures, which were intended for use in boron neutron capture therapy, was investigated. All three types of boron lipids contained the anionic dodecaborate cluster as the headgroup. Their effects on two different tumor models in mice following intravenous injection were tested; for this, liposomes with boron lipid, distearoyl phosphatidylcholine, and cholesterol as helper lipids, and containing a polyethylene glycol lipid for steric protection, were administered intravenously into tumor-bearing mice (C3H mice for SCCVII squamous cell carcinoma and BALB/c mice for CT26/WT colon carcinoma). With the exception of one lipid (B-THF-14), the lipids were well tolerated, and no other animal was lost due to systemic toxicity. The lipid which led to death was not found to be much more toxic in cell culture than the other boron lipids. All of the lipids that were well tolerated showed hemorrhage in both tumor models within a few hours after administration. The hemorrhage could be seen by in vivo magnetic resonance and histology, and was found to occur within a few hours. The degree of hemorrhage depended on the amount of boron administered and on the tumor model. The observed unwanted effect of the lipids precludes their use in boron neutron capture therapy. |
format | Online Article Text |
id | pubmed-4122578 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-41225782014-08-11 Hemorrhage in mouse tumors induced by dodecaborate cluster lipids intended for boron neutron capture therapy Schaffran, Tanja Jiang, Nan Bergmann, Markus Küstermann, Ekkehard Süss, Regine Schubert, Rolf Wagner, Franz M Awad, Doaa Gabel, Detlef Int J Nanomedicine Original Research The potential of boron-containing lipids with three different structures, which were intended for use in boron neutron capture therapy, was investigated. All three types of boron lipids contained the anionic dodecaborate cluster as the headgroup. Their effects on two different tumor models in mice following intravenous injection were tested; for this, liposomes with boron lipid, distearoyl phosphatidylcholine, and cholesterol as helper lipids, and containing a polyethylene glycol lipid for steric protection, were administered intravenously into tumor-bearing mice (C3H mice for SCCVII squamous cell carcinoma and BALB/c mice for CT26/WT colon carcinoma). With the exception of one lipid (B-THF-14), the lipids were well tolerated, and no other animal was lost due to systemic toxicity. The lipid which led to death was not found to be much more toxic in cell culture than the other boron lipids. All of the lipids that were well tolerated showed hemorrhage in both tumor models within a few hours after administration. The hemorrhage could be seen by in vivo magnetic resonance and histology, and was found to occur within a few hours. The degree of hemorrhage depended on the amount of boron administered and on the tumor model. The observed unwanted effect of the lipids precludes their use in boron neutron capture therapy. Dove Medical Press 2014-07-29 /pmc/articles/PMC4122578/ /pubmed/25114527 http://dx.doi.org/10.2147/IJN.S65166 Text en © 2014 Schaffran et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Schaffran, Tanja Jiang, Nan Bergmann, Markus Küstermann, Ekkehard Süss, Regine Schubert, Rolf Wagner, Franz M Awad, Doaa Gabel, Detlef Hemorrhage in mouse tumors induced by dodecaborate cluster lipids intended for boron neutron capture therapy |
title | Hemorrhage in mouse tumors induced by dodecaborate cluster lipids intended for boron neutron capture therapy |
title_full | Hemorrhage in mouse tumors induced by dodecaborate cluster lipids intended for boron neutron capture therapy |
title_fullStr | Hemorrhage in mouse tumors induced by dodecaborate cluster lipids intended for boron neutron capture therapy |
title_full_unstemmed | Hemorrhage in mouse tumors induced by dodecaborate cluster lipids intended for boron neutron capture therapy |
title_short | Hemorrhage in mouse tumors induced by dodecaborate cluster lipids intended for boron neutron capture therapy |
title_sort | hemorrhage in mouse tumors induced by dodecaborate cluster lipids intended for boron neutron capture therapy |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122578/ https://www.ncbi.nlm.nih.gov/pubmed/25114527 http://dx.doi.org/10.2147/IJN.S65166 |
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