SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer

Deregulation in lysine methylation signaling has emerged as a common etiologic factor in cancer pathogenesis, with inhibitors of several histone lysine methyltransferases (KMTs) being developed as chemotherapeutics(1). The largely cytoplasmic KMT SMYD3 (SET and MYND domain containing protein 3) is o...

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Detalles Bibliográficos
Autores principales: Mazur, Pawel K., Reynoird, Nicolas, Khatri, Purvesh, Jansen, Pascal W.T.C., Wilkinson, Alex, Liu, Shichong, Barbash, Olena, Van Aller, Glenn S., Huddleston, Michael, Dhanak, Dashyant, Tummino, Peter J., Kruger, Ryan G., Garcia, Benjamin, Butte, Atul J., Vermeulen, Michiel, Sage, Julien, Gozani, Or
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122675/
https://www.ncbi.nlm.nih.gov/pubmed/24847881
http://dx.doi.org/10.1038/nature13320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122675/
https://www.ncbi.nlm.nih.gov/pubmed/24847881
http://dx.doi.org/10.1038/nature13320

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