Reduced drug incorporation into DNA and antiapoptosis as the crucial mechanisms of resistance in a novel nelarabine-resistant cell line

BACKGROUND: Nine-beta-D-arabinofuranosylguanine (ara-G), an active metabolite of nelarabine, enters leukemic cells through human Equilibrative Nucleoside Transporter 1, and is then phosphorylated to an intracellular active metabolite ara-G triphosphate (ara-GTP) by both cytosolic deoxycytidine kinas...

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Detalles Bibliográficos
Autores principales: Yamauchi, Takahiro, Uzui, Kanako, Nishi, Rie, Shigemi, Hiroko, Ueda, Takanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122765/
https://www.ncbi.nlm.nih.gov/pubmed/25070259
http://dx.doi.org/10.1186/1471-2407-14-547

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