Short-Term Insulin Requirements Following Gastric Bypass Surgery in Severely Obese Women with Type 1 Diabetes

BACKGROUND: In severely obese type 2 diabetes patients, gastric bypass surgery (GB) reduces body mass index (BMI) and hemoglobin A1c (HbA1c) and allows reduced doses of insulin and other medications. Data regarding the effects of GB on severely obese patients with type 1 diabetes are limited. METHOD...

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Detalles Bibliográficos
Autores principales: Middelbeek, Roeland J. W., James-Todd, Tamarra, Patti, Mary-Elizabeth, Brown, Florence M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2014
Materias:
Original Contributions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122809/
https://www.ncbi.nlm.nih.gov/pubmed/24668543
http://dx.doi.org/10.1007/s11695-014-1228-8
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author Middelbeek, Roeland J. W.
James-Todd, Tamarra
Patti, Mary-Elizabeth
Brown, Florence M.
author_facet Middelbeek, Roeland J. W.
James-Todd, Tamarra
Patti, Mary-Elizabeth
Brown, Florence M.
author_sort Middelbeek, Roeland J. W.
collection PubMed
description BACKGROUND: In severely obese type 2 diabetes patients, gastric bypass surgery (GB) reduces body mass index (BMI) and hemoglobin A1c (HbA1c) and allows reduced doses of insulin and other medications. Data regarding the effects of GB on severely obese patients with type 1 diabetes are limited. METHODS: Severely obese women with type 1 diabetes (n = 9) were studied immediately before and after GB (7.7 ± 5.8 weeks, mean ± SD). RESULTS: On average, GB reduced mean BMI by 11 % and mean HbA1c by 0.9 % (from 8.0 to 7.1 %), with a parallel 38 % decrease in basal insulin requirements (expressed per kilogram of body weight). CONCLUSION: GB rapidly decreased BMI, HbA1c, and insulin requirements in severely obese women with type 1 diabetes. However, physiologic insulin replacement remains necessary in patients with type 1 diabetes.
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spelling pubmed-41228092014-08-08 Short-Term Insulin Requirements Following Gastric Bypass Surgery in Severely Obese Women with Type 1 Diabetes Middelbeek, Roeland J. W. James-Todd, Tamarra Patti, Mary-Elizabeth Brown, Florence M. Obes Surg Original Contributions BACKGROUND: In severely obese type 2 diabetes patients, gastric bypass surgery (GB) reduces body mass index (BMI) and hemoglobin A1c (HbA1c) and allows reduced doses of insulin and other medications. Data regarding the effects of GB on severely obese patients with type 1 diabetes are limited. METHODS: Severely obese women with type 1 diabetes (n = 9) were studied immediately before and after GB (7.7 ± 5.8 weeks, mean ± SD). RESULTS: On average, GB reduced mean BMI by 11 % and mean HbA1c by 0.9 % (from 8.0 to 7.1 %), with a parallel 38 % decrease in basal insulin requirements (expressed per kilogram of body weight). CONCLUSION: GB rapidly decreased BMI, HbA1c, and insulin requirements in severely obese women with type 1 diabetes. However, physiologic insulin replacement remains necessary in patients with type 1 diabetes. Springer US 2014-03-26 2014 /pmc/articles/PMC4122809/ /pubmed/24668543 http://dx.doi.org/10.1007/s11695-014-1228-8 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/4.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Contributions
Middelbeek, Roeland J. W.
James-Todd, Tamarra
Patti, Mary-Elizabeth
Brown, Florence M.
Short-Term Insulin Requirements Following Gastric Bypass Surgery in Severely Obese Women with Type 1 Diabetes
title Short-Term Insulin Requirements Following Gastric Bypass Surgery in Severely Obese Women with Type 1 Diabetes
title_full Short-Term Insulin Requirements Following Gastric Bypass Surgery in Severely Obese Women with Type 1 Diabetes
title_fullStr Short-Term Insulin Requirements Following Gastric Bypass Surgery in Severely Obese Women with Type 1 Diabetes
title_full_unstemmed Short-Term Insulin Requirements Following Gastric Bypass Surgery in Severely Obese Women with Type 1 Diabetes
title_short Short-Term Insulin Requirements Following Gastric Bypass Surgery in Severely Obese Women with Type 1 Diabetes
title_sort short-term insulin requirements following gastric bypass surgery in severely obese women with type 1 diabetes
topic Original Contributions
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122809/
https://www.ncbi.nlm.nih.gov/pubmed/24668543
http://dx.doi.org/10.1007/s11695-014-1228-8
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