Target Engagement Analysis and Link to Pharmacodynamic Endpoint for a Novel Class of CNS-penetrant and Efficacious p38α MAPK Inhibitors

The protein kinase, p38α MAPK, is a key intracellular transducer of stressor-induced neuroinflammatory responses and, as such, is of high interest as a potential therapeutic target. We recently reported the synthesis and evaluation of first-in-class CNS-penetrant and highly specific p38 MAPK inhibit...

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Detalles Bibliográficos
Autores principales: Bachstetter, Adam D., Watterson, D. Martin, Van Eldik, Linda J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2014
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122817/
https://www.ncbi.nlm.nih.gov/pubmed/24789302
http://dx.doi.org/10.1007/s11481-014-9543-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122817/
https://www.ncbi.nlm.nih.gov/pubmed/24789302
http://dx.doi.org/10.1007/s11481-014-9543-3

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