EC-BLAST: A Tool to Automatically Search and Compare Enzyme Reactions

EC-BLAST is an algorithm for quantitative similarity searches between enzyme reactions at three levels a) bond change, b) reaction centre and c) reaction structure similarity. It exploits the knowledge of bond changes and reaction patterns for all known biochemical reactions derived from atom-atom m...

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Detalles Bibliográficos
Autores principales: Rahman, Syed Asad, Cuesta, Sergio Martinez, Furnham, Nicholas, Holliday, Gemma L., Thornton, Janet M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122987/
https://www.ncbi.nlm.nih.gov/pubmed/24412978
http://dx.doi.org/10.1038/nmeth.2803
Descripción
Sumario:EC-BLAST is an algorithm for quantitative similarity searches between enzyme reactions at three levels a) bond change, b) reaction centre and c) reaction structure similarity. It exploits the knowledge of bond changes and reaction patterns for all known biochemical reactions derived from atom-atom mapping (AAM) across each reaction. This has the potential to improve the established enzyme classification system, to find novel biochemical transformations, to improve the assignment of enzyme function to sequences, as well as for the re-engineering of enzymes. EC-BLAST URL: http://www.ebi.ac.uk/thornton-srv/software/rbl/

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