EC-BLAST: A Tool to Automatically Search and Compare Enzyme Reactions

EC-BLAST is an algorithm for quantitative similarity searches between enzyme reactions at three levels a) bond change, b) reaction centre and c) reaction structure similarity. It exploits the knowledge of bond changes and reaction patterns for all known biochemical reactions derived from atom-atom m...

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Detalles Bibliográficos
Autores principales: Rahman, Syed Asad, Cuesta, Sergio Martinez, Furnham, Nicholas, Holliday, Gemma L., Thornton, Janet M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122987/
https://www.ncbi.nlm.nih.gov/pubmed/24412978
http://dx.doi.org/10.1038/nmeth.2803
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author Rahman, Syed Asad
Cuesta, Sergio Martinez
Furnham, Nicholas
Holliday, Gemma L.
Thornton, Janet M.
author_facet Rahman, Syed Asad
Cuesta, Sergio Martinez
Furnham, Nicholas
Holliday, Gemma L.
Thornton, Janet M.
author_sort Rahman, Syed Asad
collection PubMed
description EC-BLAST is an algorithm for quantitative similarity searches between enzyme reactions at three levels a) bond change, b) reaction centre and c) reaction structure similarity. It exploits the knowledge of bond changes and reaction patterns for all known biochemical reactions derived from atom-atom mapping (AAM) across each reaction. This has the potential to improve the established enzyme classification system, to find novel biochemical transformations, to improve the assignment of enzyme function to sequences, as well as for the re-engineering of enzymes. EC-BLAST URL: http://www.ebi.ac.uk/thornton-srv/software/rbl/
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spelling pubmed-41229872014-08-06 EC-BLAST: A Tool to Automatically Search and Compare Enzyme Reactions Rahman, Syed Asad Cuesta, Sergio Martinez Furnham, Nicholas Holliday, Gemma L. Thornton, Janet M. Nat Methods Article EC-BLAST is an algorithm for quantitative similarity searches between enzyme reactions at three levels a) bond change, b) reaction centre and c) reaction structure similarity. It exploits the knowledge of bond changes and reaction patterns for all known biochemical reactions derived from atom-atom mapping (AAM) across each reaction. This has the potential to improve the established enzyme classification system, to find novel biochemical transformations, to improve the assignment of enzyme function to sequences, as well as for the re-engineering of enzymes. EC-BLAST URL: http://www.ebi.ac.uk/thornton-srv/software/rbl/ 2014-01-12 2014-02 /pmc/articles/PMC4122987/ /pubmed/24412978 http://dx.doi.org/10.1038/nmeth.2803 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Rahman, Syed Asad
Cuesta, Sergio Martinez
Furnham, Nicholas
Holliday, Gemma L.
Thornton, Janet M.
EC-BLAST: A Tool to Automatically Search and Compare Enzyme Reactions
title EC-BLAST: A Tool to Automatically Search and Compare Enzyme Reactions
title_full EC-BLAST: A Tool to Automatically Search and Compare Enzyme Reactions
title_fullStr EC-BLAST: A Tool to Automatically Search and Compare Enzyme Reactions
title_full_unstemmed EC-BLAST: A Tool to Automatically Search and Compare Enzyme Reactions
title_short EC-BLAST: A Tool to Automatically Search and Compare Enzyme Reactions
title_sort ec-blast: a tool to automatically search and compare enzyme reactions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122987/
https://www.ncbi.nlm.nih.gov/pubmed/24412978
http://dx.doi.org/10.1038/nmeth.2803
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AT hollidaygemmal ecblastatooltoautomaticallysearchandcompareenzymereactions
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